• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

严重肥胖伴低瘦素血症。

Severe obesity with hypo-leptinemia.

作者信息

Kita Masanori, Morita Shuhei, Ariyasu Hiroyuki, Tsuji Tomoya, Uraki Shinsuke, Takeshima Ken, Iwakura Hiroshi, Matsuoka Taka-Aki

机构信息

First Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.

Department of Diabetes and Endocrinology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.

出版信息

Endocr J. 2025 Jul 1;72(7):801-811. doi: 10.1507/endocrj.EJ24-0568. Epub 2025 Mar 22.

DOI:10.1507/endocrj.EJ24-0568
PMID:40128964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12260190/
Abstract

Some cases of obesity are thought to be associated with hypo-leptinemia. This may cause decreased appetite suppression resulting in increased appetite, leading to weight gain. Replacement therapy with leptin might be theoretically useful, but verification by reporting more cases is required. Here, we first investigated the serum leptin levels and their correlation with body mass index (BMI) in 107 patients with obesity to identify the subjects with hypo-leptinemia. Among them, one patient with congenital hypopituitarism was further investigated by comparison of his clinical and pathological characteristics with those of control subjects. This 40-year-old Japanese man, who was large from birth, consistently showed obesity of more than 2SD during his growth period. He had 41.5 kg/m at BMI with central hypogonadism, central diabetes insipidus and severe growth hormone deficiency, cognitive impairment, and abnormal eating behavior, which led to suspicion of the involvement of hypothalamic factors. Genetic analysis revealed no definite mutations regarding metabolic and nutritional systems or adipocytes including leptin-related genes. Electron microscopic images of subcutaneous adipose tissue demonstrated relatively smaller adipocytes compared with a BMI-matched patient. The patient suffered from his abnormal eating behavior, began dialysis at the age of 41 years, and died of bacterial pneumonia at 49 years of age. Among patients with severe obesity with hypo-leptinemia, there could be patients with disturbance of healthy expansion in adipocyte, probably due to unknown dysfunction. Even with the lack of abnormality of leptin-related genes, indication of leptin-replacement may be considered for severely obese patients with hypo-leptinemia.

摘要

一些肥胖病例被认为与低瘦素血症有关。这可能导致食欲抑制减弱，从而食欲增加，进而导致体重增加。理论上，用瘦素进行替代疗法可能有用，但需要通过报告更多病例来加以验证。在此，我们首先调查了107例肥胖患者的血清瘦素水平及其与体重指数（BMI）的相关性，以确定低瘦素血症患者。其中，一名先天性垂体功能减退患者通过将其临床和病理特征与对照受试者进行比较，作了进一步研究。这名40岁的日本男性自幼体型庞大，在生长期间BMI始终超过2个标准差。他的BMI为41.5kg/m²，伴有中枢性性腺功能减退、中枢性尿崩症和严重的生长激素缺乏、认知障碍以及异常饮食行为，这引发了对下丘脑因素参与其中的怀疑。基因分析未发现与代谢和营养系统或包括瘦素相关基因在内的脂肪细胞有关的明确突变。皮下脂肪组织的电子显微镜图像显示，与一名BMI匹配的患者相比，其脂肪细胞相对较小。该患者受异常饮食行为困扰，41岁开始透析，49岁死于细菌性肺炎。在患有严重肥胖和低瘦素血症的患者中，可能存在脂肪细胞健康扩张受干扰的患者，这可能是由于未知的功能障碍所致。即使瘦素相关基因没有异常，对于患有严重肥胖和低瘦素血症的患者，也可考虑给予瘦素替代治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/ad31f08a4671/72_EJ24-0568_GA.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/51e6878e35f3/72_EJ24-0568_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/ef433cfd9196/72_EJ24-0568_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/c5b58d17c9a8/72_EJ24-0568_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/bc873c1f5e41/72_EJ24-0568_4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/c09f05483a9f/72_EJ24-0568_5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/efaa2e2d1c58/72_EJ24-0568_6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/534f301614ca/72_EJ24-0568_7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/eb1e3f1db255/72_EJ24-0568_8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/edfd0b20536d/72_EJ24-0568_9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/4d5df6aabc84/72_EJ24-0568_10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/6dac12dac2b7/72_EJ24-0568_11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/ad31f08a4671/72_EJ24-0568_GA.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/51e6878e35f3/72_EJ24-0568_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/ef433cfd9196/72_EJ24-0568_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/c5b58d17c9a8/72_EJ24-0568_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/bc873c1f5e41/72_EJ24-0568_4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/c09f05483a9f/72_EJ24-0568_5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/efaa2e2d1c58/72_EJ24-0568_6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/534f301614ca/72_EJ24-0568_7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/eb1e3f1db255/72_EJ24-0568_8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/edfd0b20536d/72_EJ24-0568_9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/4d5df6aabc84/72_EJ24-0568_10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/6dac12dac2b7/72_EJ24-0568_11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/12260190/ad31f08a4671/72_EJ24-0568_GA.jpg

相似文献

1
Severe obesity with hypo-leptinemia.严重肥胖伴低瘦素血症。
Endocr J. 2025 Jul 1;72(7):801-811. doi: 10.1507/endocrj.EJ24-0568. Epub 2025 Mar 22.
2
Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes.孕期超重或肥胖女性使用二甲双胍以改善母婴结局。
Cochrane Database Syst Rev. 2018 Jul 24;7(7):CD010564. doi: 10.1002/14651858.CD010564.pub2.
3
The Black Book of Psychotropic Dosing and Monitoring.《精神药物剂量与监测黑皮书》
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.
4
Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception.COVID-19 患者使用激素避孕的血栓栓塞风险。
Cochrane Database Syst Rev. 2023 Jan 9;1(1):CD014908. doi: 10.1002/14651858.CD014908.pub2.
5
Falls prevention interventions for community-dwelling older adults: systematic review and meta-analysis of benefits, harms, and patient values and preferences.社区居住的老年人跌倒预防干预措施：系统评价和荟萃分析的益处、危害以及患者的价值观和偏好。
Syst Rev. 2024 Nov 26;13(1):289. doi: 10.1186/s13643-024-02681-3.
6
Home treatment for mental health problems: a systematic review.心理健康问题的居家治疗：一项系统综述
Health Technol Assess. 2001;5(15):1-139. doi: 10.3310/hta5150.
7
Sexual Harassment and Prevention Training性骚扰与预防培训
8
Sertindole for schizophrenia.用于治疗精神分裂症的舍吲哚。
Cochrane Database Syst Rev. 2005 Jul 20;2005(3):CD001715. doi: 10.1002/14651858.CD001715.pub2.
9
The quantity, quality and findings of network meta-analyses evaluating the effectiveness of GLP-1 RAs for weight loss: a scoping review.评估胰高血糖素样肽-1受体激动剂（GLP-1 RAs）减肥效果的网状Meta分析的数量、质量及结果：一项范围综述
Health Technol Assess. 2025 Jun 25:1-73. doi: 10.3310/SKHT8119.
10
Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years.6至11岁超重或肥胖儿童治疗中的饮食、身体活动及行为干预措施
Cochrane Database Syst Rev. 2017 Jun 22;6(6):CD012651. doi: 10.1002/14651858.CD012651.

引用本文的文献

1
Assessing the causal relationship between obesity and ankylosing spondylitis: A two-sample Mendelian randomization study.评估肥胖与强直性脊柱炎之间的因果关系：一项两样本孟德尔随机化研究。
Medicine (Baltimore). 2025 May 23;104(21):e42559. doi: 10.1097/MD.0000000000042559.

本文引用的文献

1
Patients with diabetes and obesity exhibit characteristics in eating and coping behaviors and personality traits.患有糖尿病和肥胖症的患者在饮食、应对行为及性格特征方面表现出一些特点。
Diabetol Int. 2024 Apr 16;15(3):528-534. doi: 10.1007/s13340-024-00721-w. eCollection 2024 Jul.
2
Bardet-Biedl syndrome improved diagnosis criteria and management: Inter European Reference Networks consensus statement and recommendations.巴德-比德尔综合征的诊断标准与管理改进：欧洲参考网络间的共识声明与建议
Eur J Hum Genet. 2024 Nov;32(11):1347-1360. doi: 10.1038/s41431-024-01634-7. Epub 2024 Jul 31.
3
Leptin receptor reactivation restores brain function in early-life Lepr-deficient mice.
瘦素受体重新激活可恢复幼年Lepr基因缺陷小鼠的脑功能。
Brain. 2024 Aug 1;147(8):2706-2717. doi: 10.1093/brain/awae127.
4
HSP47 levels determine the degree of body adiposity.HSP47 水平决定了身体肥胖程度。
Nat Commun. 2023 Nov 11;14(1):7319. doi: 10.1038/s41467-023-43080-x.
5
A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.全国多中心瘦素及瘦素受体缺乏症研究及系统评价
J Clin Endocrinol Metab. 2023 Aug 18;108(9):2371-2388. doi: 10.1210/clinem/dgad099.
6
Bardet-Biedl Syndrome-Multiple Kaleidoscope Images: Insight into Mechanisms of Genotype-Phenotype Correlations.Bardet-Biedl 综合征-多种万花筒图像：对基因型-表型相关性机制的深入了解。
Genes (Basel). 2021 Aug 29;12(9):1353. doi: 10.3390/genes12091353.
7
Practice guideline for lipodystrophy syndromes-clinically important diseases of the Japan Endocrine Society (JES).脂肪营养不良综合征临床实践指南——日本内分泌学会（JES）的重要临床疾病
Endocr J. 2021 Sep 28;68(9):1027-1042. doi: 10.1507/endocrj.EJ21-0110. Epub 2021 Aug 7.
8
Why primary obesity is a disease?为什么原发性肥胖是一种疾病？
J Transl Med. 2019 May 22;17(1):169. doi: 10.1186/s12967-019-1919-y.
9
Identification of a variant associated with early-onset diabetes in the intron of the insulin gene with exome sequencing.外显子组测序鉴定胰岛素基因内含子中与早发糖尿病相关的变异体。
J Diabetes Investig. 2019 Jul;10(4):947-950. doi: 10.1111/jdi.12974. Epub 2018 Dec 5.
10
Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans.男性肥胖人群中，腹部皮下和内脏脂肪细胞的大小、脂肪分解和炎症与胰岛素抵抗有关。
Sci Rep. 2018 Mar 16;8(1):4677. doi: 10.1038/s41598-018-22962-x.