Sapkota Biswash, Pandey Bipindra, Sapkota Bishal, Dhakal Keshav, Aryal Bijay
Department of Pharmacy and Clinical Pharmacology, Madan Bhandari Academy of Health Sciences, Hetauda, Nepal.
Department of General Practice and Emergency Medicine, Patan Academy of Health Sciences, Lalitpur, Nepal.
PLoS One. 2025 Mar 25;20(3):e0320181. doi: 10.1371/journal.pone.0320181. eCollection 2025.
Pharmacists are essential for developing pharmacotherapy plans, conducting clinical assessments, and overseeing drug monitoring. Their interventions help prevent medication errors and adverse drug events and enhance medication safety. This study aimed to systematically review pharmacist-led interventions for managing medication-related issues in patients receiving anti-ulcer treatments. A systematic review and meta-analysis was performed to explore four databases for studies published from 1904 up to June 2024. Nine studies were reviewed, including four retrospective, three case-control, one mixed-method, and one prospective pre-post study involving 34,099 participants. The average age of the patients was 61 years, and 50.23% were male. The study quality was high, with an average score of 6.22/7 on the modified Newcastle-Ottawa scale. All studies involved direct interactions between pharmacists and patients or physicians, and data were primarily collected from hospital electronic records. Pooled analysis demonstrated that pharmacist interventions significantly improved the rational use of anti-ulcer medications (OR: 4.5; 95% CI: 0.97 to 20.80; I2 = 89%, P = 0.05), as reported by studies. Pharmacist interventions have a significant impact on improving rational drug use, reducing costs and treatment duration, and enhancing appropriate medication use. These interventions also positively influenced medication adherence and the correction of irrational drug use.
药剂师对于制定药物治疗方案、进行临床评估以及监督药物监测至关重要。他们的干预有助于预防用药错误和药物不良事件，并提高用药安全性。本研究旨在系统评价药剂师主导的干预措施对接受抗溃疡治疗患者的药物相关问题的管理效果。进行了一项系统评价和荟萃分析，以检索1904年至2024年6月发表的研究的四个数据库。共审查了9项研究，包括4项回顾性研究、3项病例对照研究、1项混合方法研究和1项前瞻性前后对照研究，涉及34099名参与者。患者的平均年龄为61岁，男性占50.23%。研究质量较高，在改良的纽卡斯尔-渥太华量表上的平均得分为6.22/7。所有研究都涉及药剂师与患者或医生之间的直接互动，数据主要从医院电子记录中收集。汇总分析表明，如研究报告所述，药剂师的干预显著改善了抗溃疡药物的合理使用（比值比：4.5；95%置信区间：0.97至20.80；I2 = 89%，P = 0.05）。药剂师的干预对改善合理用药、降低成本和缩短治疗时间以及提高用药合理性有显著影响。这些干预还对用药依从性和纠正不合理用药产生了积极影响。
