Boeri Luca, Pozzi Edoardo, Belladelli Federico, Cattafi Francesco, Cilio Simone, Bertini Alessandro, Raffo Massimiliano, Negri Fausto, Corsini Christian, Capogrosso Paolo, d'Arma Alessia, Montorsi Francesco, Salonia Andrea
Department of Urology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Division of Experimental Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Milan, Italy.
Int J Impot Res. 2025 Mar 25. doi: 10.1038/s41443-025-01013-w.
We aimed to assess the clinical characteristics of patients presenting for premature ejaculation (PE) as their primary medical complaint over a 15-year time frame. Data from 257 men seeking first medical help for life-long PE between 2008 and 2022 were analysed. Clinical data and serum hormones were collected in each case. At baseline all patients completed the International Index of Erectile Function (IIEF), the Beck Depression Inventory (BDI), and the Premature Ejaculation Diagnostic Tool (PEDT). Descriptive statistics and linear regression analyses were applied. Median (IQR) age at presentation was 32 (26-37) years, and PEDT, BDI and IIEF-Erectile Function (IIEF-EF) scores were 14 (11-17), 7 (1-11) and 19 (10-26), respectively. Of all, 182 (70.9%) patients reported some degree of erectile dysfunction according to IIEF-EF domain scores. Throughout the 15-year time frame, patient's age at presentation significantly decreased over time (beta -0.4, p < 0.001). In details, patient's age at presentation decreased by 1 year every two years of evaluation. Furthermore, depressive symptoms (beta -0.8, p < 0.001) and the severity of PE at presentation as scored with the PEDT (beta -0.5, p < 0.001) linearly decreased overtime. According to a 5-year group subdivision, age at presentation decreased from 2008-2012 to 2013-2017 (p = 0.04) and further decreased between 2018 and 2022 (p = 0.01). Similarly, baseline BDI scores significantly decreased from 2008-2012 to 2018-2022 (all p < 0.001). PE severity at first assessment was stable between 2008-2012 and 2013-2017 but decreased thereafter (p < 0.01). Patients in a steady couple relationship more frequently asked for medical attention for PE between 2018-2022 compared to 2013-2017 and 2008-2012 (72.0% vs. 43.8% vs. 51.6%, p < 0.001). In conclusion we showed that patients' age has decreased over the last 15 years in men with life-long PE. PE severity and depressive symptoms at presentation showed a significant decline overtime. Men in a steady sexual relationship were more likely to seek medical attention for PE in recent years.
我们旨在评估在15年时间范围内，以早泄（PE）作为主要医疗诉求前来就诊的患者的临床特征。分析了2008年至2022年间257名因终生早泄首次寻求医疗帮助的男性的数据。收集了每个病例的临床数据和血清激素。在基线时，所有患者均完成了国际勃起功能指数（IIEF）、贝克抑郁量表（BDI）和早泄诊断工具（PEDT）。应用了描述性统计和线性回归分析。就诊时的中位（IQR）年龄为32（26 - 37）岁，PEDT、BDI和IIEF勃起功能（IIEF - EF）评分分别为14（11 - 17）、7（1 - 11）和19（10 - 26）。根据IIEF - EF领域评分，所有患者中有182例（70.9%）报告有一定程度的勃起功能障碍。在整个15年时间范围内，患者的就诊年龄随时间显著下降（β -0.4，p < 0.001）。具体而言，每两年评估患者的就诊年龄下降1岁。此外，抑郁症状（β -0.8，p < 0.001）和就诊时用PEDT评分的PE严重程度（β -0.5，p < 0.001）随时间呈线性下降。根据5年分组细分，就诊年龄从2008 - 2012年到2013 - 2017年下降（p = 0.04），在2018年至2022年之间进一步下降（p = 0.01）。同样，基线BDI评分从2008 - 2012年到2018 - 2022年显著下降（所有p < 0.001）。首次评估时的PE严重程度在2008 - 2012年和2013 - 2017年之间稳定，但此后下降（p < 0.01）。与2013 - 2017年和2008 - 2012年相比，处于稳定伴侣关系的患者在2018 - 2022年期间因PE寻求医疗关注的频率更高（72.0%对43.8%对51.6%，p <
