Zeng Zhaohao, Xiong Lijiao, Cen Yanmei, Hong Guo, Shen Yingao, Luo Xiaoguang
Department of Neurology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518001 Shenzhen, Guangdong, China.
The First Clinical Medical College of Jinan University, 510632 Guangzhou, Guangdong, China.
Int J Vitam Nutr Res. 2024 Dec 18;95(1):36422. doi: 10.31083/IJVNR36422.
Parkinson's disease (PD) is a chronic progressive neurodegenerative disease, and the exact etiology of PD has not been fully elucidated. Changes in dietary patterns play an important role in the onset and progression of PD. However, the association between specific dietary factors and PD remains unclear.
A total of 14,309 subjects from the National Health and Nutrition Examination Survey (NHANES) (2007-2016) were included. Logistic regression was used to analyze the association between 34 nutrients and PD. The regression model was adjusted for potential confounders and effect modifiers including age, gender, race, education, hypertension, and stroke.
The data showed negative associations of the intake of protein (0.99 (0.98, 1.00), = 0.018), fiber (0.96 (0.93, 0.99), = 0.003), vitamin E (0.91 (0.86, 0.97), = 0.005), copper (0.55 (0.36, 0.86), = 0.009) with PD. Alpha carotene ( = 0.042), beta-carotene ( = 0.006), phosphorus ( = 0.018), magnesium ( = 0.002), sodium ( = 0.035), potassium ( = 0.001) had a potential negative correlation with PD. The intake of carbohydrate, sugars, fat, cholesterol, vitamin A, beta-cryptoxanthin, lycopene, lutein zeaxanthin, vitamin B1, vitamin B2, niacin, vitamin B6, folate, vitamin B12, vitamin C, vitamin D, vitamin K, calcium, iron, zinc, selenium, caffeine, theobromine, alcohol was not associated with PD ( > 0.05).
Some specific dietary elements are associated with PD, and supplementation of dietary elements may have potentially beneficial effects. However, the observed associations between dietary factors and PD may be influenced by changes in diet resulting from the disease itself, rather than diet influencing PD risk. Further longitudinal studies are needed to establish causal relationships and directionality.
帕金森病（PD）是一种慢性进行性神经退行性疾病，其确切病因尚未完全阐明。饮食模式的变化在PD的发病和进展中起重要作用。然而，特定饮食因素与PD之间的关联仍不清楚。
纳入了来自美国国家健康与营养检查调查（NHANES）（2007 - 2016年）的14309名受试者。采用逻辑回归分析34种营养素与PD之间的关联。回归模型针对潜在的混杂因素和效应修饰因素进行了调整，包括年龄、性别、种族、教育程度、高血压和中风。
数据显示蛋白质摄入量（0.99（0.98，1.00），P = 0.018）、纤维摄入量（0.96（0.93，0.99），P = 0.003）、维生素E摄入量（0.91（0.86，0.97），P = 0.005）、铜摄入量（0.55（0.36，0.86），P = 0.009）与PD呈负相关。α - 胡萝卜素（P = 0.042）、β - 胡萝卜素（P = 0.006）、磷（P = 0.018）、镁（P = 0.002）、钠（P = 0.035）、钾（P = 0.001）与PD有潜在的负相关。碳水化合物、糖、脂肪、胆固醇、维生素A、β - 隐黄质、番茄红素、叶黄素玉米黄质、维生素B1、维生素B2、烟酸、维生素B6、叶酸、维生素B12、维生素C、维生素D、维生素K、钙、铁、锌、硒、咖啡因、可可碱、酒精的摄入量与PD无关（P > 0.05）。
一些特定的饮食元素与PD有关，补充饮食元素可能具有潜在的有益作用。然而，观察到的饮食因素与PD之间的关联可能受到疾病本身导致的饮食变化影响，而非饮食影响PD风险。需要进一步的纵向研究来建立因果关系和方向性。
