Rizvi Meher, Malhotra Shalini, Sami Hiba, Agarwal Jyotsna, Siddiqui Areena H, Devi Sheela, Poojary Aruna, Thakuria Bhaskar, Princess Isabella, Gupta Aarti, Al Malehi Amal, Sultan Asfia, Jitendranath Ashish, Mohan Balvinder, Khan Fatima, Tahir Hatim El, Ilanchezhiyan Nainaraj, Jain Mannu, Khan Maria, Singh Narendra Pal, Gur Renu, Mohapatra Sarita, Farooq Shaika, Yamunadevi Vellore Ramanathan, Masters Ken, Goyal Nisha, Sen Manodeep, Zadjali Razan Al, Rajendradas Rugma, Meena Suneeta, Dutta Sudip, Langford Bradley, Kanungo Reba, Jabri Zaaima Al, Rajaibi Arwa Al, Singh Sanjeev, Mamari Azza Al, Singh Sarman, John Keith H St, Sardana Raman, Kapoor Pawan, Jardani Amina Al, Soman Rajeev, Balkhair Abdullah, Taneja Neelam
Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Department of Microbiology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, New Delhi, India.
IJID Reg. 2025 Feb 19;14:100605. doi: 10.1016/j.ijregi.2025.100605. eCollection 2025 Mar.
Knowledge of local antibiotic susceptibility rates is essential to strengthen antimicrobial stewardship programs. (https://dashuti.com/), promotes the dissemination of focused local antibiograms in community urinary tract infection (UTI). This study mapped the susceptibility profile of from 18 Indian centers.
The centers spanned nine Indian States and three Union Territories. Urinary antibiograms from the outpatient clinic were collated and analyzed. Standardization was achieved through online training. For epidemiological purposes, five centers tested fosfomycin.
Overall, low susceptibility (<60%) was observed for the standard oral antibiotics prescribed for cystitis: co-trimoxazole, 54% (36-68%); ciprofloxacin, 52% (29-55%); amoxicillin-clavulanic acid, 46%, (35-82%); nitrofurantoin, 39% (19-78%); and cefuroxime, 30% (15-62%). The rates for third- and fourth-generation cephalosporins were 49% (45-52%) and 60% (36-76%), respectively. Extended-spectrum beta-lactamases ranged from 36-61% in India. Piperacillin-tazobactam 74% (65-87%), amikacin 76% (45-91%), and meropenem 81% (61-87%) exhibited higher activity. Fosfomycin was the most active antimicrobial, with 89% (92-97%) susceptibility. susceptibility was directly linked to geographic region, log gross domestic product ( <0.001), and humidity, and low and high temperatures ( <0.05).
Oral treatment options for cystitis are rapidly decreasing. Northern and southern India showed significant differences in antimicrobial susceptibility, highlighting the importance of local antibiograms for promoting antimicrobial stewardship. For uncomplicated cystitis, co-trimoxazole (54%) may be the empirical choice. Good susceptibility to fosfomycin was observed (89%). The empirical use of fluoroquinolones, cephalosporins, and amoxicillin-clavulanic acid has been discouraged. Piperacillin-tazobactam and aminoglycosides are carbapenem-sparing agents.
了解当地抗生素敏感性率对于加强抗菌药物管理计划至关重要。（https://dashuti.com/），促进在社区尿路感染（UTI）中传播有针对性的当地抗菌谱。本研究描绘了来自印度18个中心的敏感性概况。
这些中心分布在印度的九个邦和三个联邦属地。整理并分析了门诊诊所的尿液抗菌谱。通过在线培训实现标准化。出于流行病学目的，五个中心检测了磷霉素。
总体而言，膀胱炎常用口服抗生素的敏感性较低（<60%）：复方新诺明为54%（36 - 68%）；环丙沙星为52%（29 - 55%）；阿莫西林 - 克拉维酸为46%（35 - 82%）；呋喃妥因39%（19 - 78%）；头孢呋辛30%（15 - 62%）。第三代和第四代头孢菌素的敏感性率分别为49%（45 - 52%）和60%（36 - 76%）。印度超广谱β - 内酰胺酶的比例在36% - 61%之间。哌拉西林 - 他唑巴坦为74%（65 - 87%），阿米卡星为76%（45 - 91%），美罗培南为81%（61 - 87%），活性较高。磷霉素是活性最高的抗菌药物，敏感性为89%（92 - 97%）。敏感性与地理区域、国内生产总值对数（<0.001）、湿度以及低温和高温（<0.05）直接相关。
膀胱炎的口服治疗选择正在迅速减少。印度北部和南部在抗菌药物敏感性方面存在显著差异，凸显了当地抗菌谱对于促进抗菌药物管理的重要性。对于单纯性膀胱炎，复方新诺明（54%）可能是经验性选择。观察到对磷霉素的敏感性良好（89%）。不鼓励经验性使用氟喹诺酮类、头孢菌素类和阿莫西林 - 克拉维酸。哌拉西林 - 他唑巴坦和氨基糖苷类是碳青霉烯类药物的替代药物。
