Bhargava Kanika, Nath Gopal, Bhargava Amit, Kumari Ritu, Aseri G K, Jain Neelam
Amity Institute of Microbial Technology, Amity University Rajasthan, Jaipur, India.
Department of Microbiology, Institute of Medical Sciences (IMS), Banaras Hindu University, Varanasi, India.
Front Microbiol. 2022 Aug 9;13:965053. doi: 10.3389/fmicb.2022.965053. eCollection 2022.
Urinary tract infection (UTI) is a common infectious disease that affects men and women. It is a significant health concern due to multidrug-resistant (MDR) organisms. Therefore, it is necessary to have a current understanding of the antibiotic susceptibility (AS) pattern of uropathogens to manage UTI effectively. Since the bacterial pathogen causing UTI and its AS vary with time and place, the prevailing AS pattern of the causative agents are essential for empirical antibiotic therapy. This study aims to determine the prevalence and AS of uropathogens isolated from UTI patients in the eastern part of Northern India. The study was carried out between November 2018 and December 2019. Clean catch midstream urine samples were collected and processed using standard guidelines for microbiological procedures. Positive microbiological cultures were found in 333 of the 427 patients, where 287 were gram-negative bacteria (GNB), and 46 were gram-positive bacteria (GPB). Females had a higher prevalence of UTI (60.7%) than males (39.3%) ( = 0.00024). The most susceptible age group in females was 18-50 years as compared to males, whereas at the age of 51-80 years and >80 years males were more susceptible than females ( = 0.053). The most prevalent pathogen identified were (55.0%), followed by sp. (6.9%), (6.6%), (6.3%), of which 96.0% were MDR bacteria. The susceptibility pattern of our study also revealed that amikacin, gentamycin and imipenem were the most effective drugs against GNB. In contrast, nitrofurantoin, vancomycin, and chloramphenicol were the most effective drugs against GPB. According tothe findings, MDR pathogens are very much prevalent. Since UTI is one of the most frequent bacterial diseases, proper management necessitates extensive investigation and implementation of antibiotic policy based on AS patterns for a particular region.
尿路感染（UTI）是一种影响男性和女性的常见传染病。由于多重耐药（MDR）微生物的存在，它是一个重大的健康问题。因此，有必要了解当前尿路病原体的抗生素敏感性（AS）模式，以便有效地管理尿路感染。由于引起UTI的细菌病原体及其AS模式会随时间和地点而变化，病原体的主要AS模式对于经验性抗生素治疗至关重要。本研究旨在确定从印度北部东部UTI患者中分离出的尿路病原体的患病率和AS。该研究于2018年11月至2019年12月进行。按照微生物学程序的标准指南收集并处理清洁中段尿样本。427例患者中有333例微生物培养呈阳性，其中287例为革兰氏阴性菌（GNB），46例为革兰氏阳性菌（GPB）。女性UTI患病率（60.7%）高于男性（39.3%）（P = 0.00024）。与男性相比，女性中最易感年龄组为18 - 50岁，而在51 - 80岁和80岁以上年龄组中，男性比女性更易感（P = 0.053）。鉴定出的最常见病原体是大肠埃希菌（55.0%），其次是肺炎克雷伯菌（6.9%）、铜绿假单胞菌（6.6%）、粪肠球菌（6.3%），其中96.0%为MDR细菌。我们研究的药敏模式还显示，阿米卡星、庆大霉素和亚胺培南是对抗GNB最有效的药物。相比之下，呋喃妥因、万古霉素和氯霉素是对抗GPB最有效的药物。根据研究结果，MDR病原体非常普遍。由于UTI是最常见的细菌性疾病之一，适当的管理需要基于特定地区的AS模式进行广泛调查并实施抗生素政策。
