Kim Nayoung, Bae Mingyu, Cho Euni, Kim Ki Su, Lee Jin-Ho
Department of Information Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea.
School of Chemical Engineering, College of Engineering, Pusan National University, Busan 46241, Republic of Korea.
Biosensors (Basel). 2025 Mar 4;15(3):165. doi: 10.3390/bios15030165.
Cancer is one of the most lethal diseases and has distinct variants that affect over 60 organs in the human body. The necessity of advanced methodologies for the early diagnosis of cancer has grown over the past decades. Among various biomarkers, microRNAs (miRNAs) have emerged as highly specific and minimally invasive indicators for cancer detection, prognosis, and treatment monitoring. Their stability in biological fluids and their critical role in gene regulation make them valuable targets for diagnostic applications. Plasmonic biosensors have gained massive attention owing to their unique optical properties, such as surface plasmon resonance, making them promising tools for the sensitive and selective analysis of cancer-associated biomarkers. In contrast to previous reviews, this work offers a comprehensive overview of advancements from approximately the past five years, particularly in the detection of cancer-associated miRNAs. It emphasizes emerging plasmonic sensing strategies, integration with novel nanomaterials, and enhanced signal amplification techniques. By focusing on these recent innovations, this review provides new insights into the potential of plasmonic biosensors to improve cancer diagnosis and treatment.
癌症是最致命的疾病之一，有不同的变体，会影响人体60多个器官。在过去几十年里，对用于癌症早期诊断的先进方法的需求不断增加。在各种生物标志物中，微小RNA（miRNA）已成为癌症检测、预后和治疗监测的高度特异性和微创指标。它们在生物体液中的稳定性以及在基因调控中的关键作用使其成为诊断应用的有价值靶点。等离子体生物传感器因其独特的光学特性，如表面等离子体共振，而受到广泛关注，使其成为用于癌症相关生物标志物灵敏和选择性分析的有前景的工具。与以往的综述不同，这项工作全面概述了大约过去五年的进展，特别是在癌症相关miRNA的检测方面。它强调了新兴的等离子体传感策略、与新型纳米材料的整合以及增强的信号放大技术。通过关注这些最新创新，本综述为等离子体生物传感器在改善癌症诊断和治疗方面的潜力提供了新的见解。
