Butt Muhammad A
Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland.
Biosensors (Basel). 2025 Jan 9;15(1):35. doi: 10.3390/bios15010035.
Surface Plasmon Resonance (SPR)-based biodetection systems have emerged as powerful tools for real-time, label-free biomolecular interaction analysis, revolutionizing fields such as diagnostics, drug discovery, and environmental monitoring. This review highlights the foundational principles of SPR, focusing on the interplay of evanescent waves and surface plasmons that underpin its high sensitivity and specificity. Recent advancements in SPR technology, including enhancements in sensor chip materials, integration with nanostructures, and coupling with complementary detection techniques, are discussed to showcase their role in improving analytical performance. The paper also explores diverse applications of SPR biodetection systems, ranging from pathogen detection and cancer biomarker identification to food safety monitoring and environmental toxin analysis. By providing a comprehensive overview of technological progress and emerging trends, this review underscores the transformative potential of SPR-based biodetection systems in addressing critical scientific and societal challenges. Future directions and challenges, including miniaturization, cost reduction, and expanding multiplexing capabilities, are also presented to guide ongoing research and development in this rapidly evolving field.
基于表面等离子体共振（SPR）的生物检测系统已成为用于实时、无标记生物分子相互作用分析的强大工具，给诊断、药物发现和环境监测等领域带来了变革。本综述重点介绍了SPR的基本原理，着重阐述了支撑其高灵敏度和特异性的倏逝波与表面等离子体的相互作用。文中讨论了SPR技术的最新进展，包括传感器芯片材料的改进、与纳米结构的集成以及与互补检测技术的耦合，以展示它们在提高分析性能方面的作用。本文还探讨了SPR生物检测系统的各种应用，从病原体检测、癌症生物标志物识别到食品安全监测和环境毒素分析。通过全面概述技术进展和新兴趋势，本综述强调了基于SPR的生物检测系统在应对关键科学和社会挑战方面的变革潜力。还介绍了未来的方向和挑战，包括小型化、降低成本和扩大复用能力，以指导这一快速发展领域的 ongoing 研究和开发。 （注：“ongoing”未翻译，因为它在英文中作形容词，此处直接保留更符合语境，若强行翻译为“正在进行的”会稍显生硬）
