Hagau Asmaa Carla, Matacuta-Bogdan Ioana-Octavia, Chiperi Lacramioara Eliza, Hack Beatrix-Jullia, Muntean Iolanda
Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540136 Târgu Mureș, Romania.
Clinic of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of Târgu Mureș, 540139 Târgu Mureș, Romania.
J Cardiovasc Dev Dis. 2025 Feb 21;12(3):82. doi: 10.3390/jcdd12030082.
Dilated cardiomyopathy (DCM) is a significant contributor to heart failure (HF) in the pediatric population despite its lower incidence compared to adults.
We present a case-control study that investigates serum levels of Vitamin D, measured as 25-hydroxyvitamin D (25-OHD), in children diagnosed with DCM and explores the relationship between Vitamin D levels and left ventricular (LV) dimensions and systolic function.
Thirty patients (mean age: 10.61 ± 6.54 years) with DCM were included, with a control group of thirty-one matched healthy children. We found a high prevalence of 25-OHD deficiency (67%) in the DCM group, which was statistically significant compared to the control group ( < 0.05). Notably, a significant negative correlation was observed between 25-OHD levels and both LV end-diastolic diameter (LVEDD; r = -0.43, < 0.01) and end-systolic diameter (LVESD; r = -0.46, < 0.01). However, no significant correlation was found between Vitamin D levels and LV ejection fraction or shortening fraction.
These findings emphasise the importance of assessing Vitamin D status in pediatric DCM patients and may suggest that Vitamin D supplementation can be beneficial in managing this condition through its potential effects on cardiac remodelling and function. Further research is warranted to clarify the underlying mechanisms and therapeutic implications.
扩张型心肌病（DCM）是导致儿童心力衰竭（HF）的一个重要因素，尽管其发病率低于成人。
我们开展了一项病例对照研究，调查诊断为DCM的儿童血清维生素D水平（以25-羟基维生素D（25-OHD）衡量），并探讨维生素D水平与左心室（LV）尺寸及收缩功能之间的关系。
纳入了30例DCM患者（平均年龄：10.61±6.54岁），并设立了一个由31名匹配的健康儿童组成的对照组。我们发现DCM组中25-OHD缺乏的患病率很高（67%），与对照组相比具有统计学意义（<0.05）。值得注意的是，观察到25-OHD水平与LV舒张末期直径（LVEDD；r = -0.43，<0.01）和收缩末期直径（LVESD；r = -0.46，<0.01）均呈显著负相关。然而，未发现维生素D水平与LV射血分数或缩短分数之间存在显著相关性。
这些发现强调了评估儿童DCM患者维生素D状态的重要性，并可能表明补充维生素D通过其对心脏重塑和功能的潜在影响，可能有助于管理这种疾病。有必要进一步研究以阐明潜在机制和治疗意义。
