Gonçalves Carolina Miguel, Vazão Adriana, Carvalho Mariana, Cabral Margarida, Martins André, Amado Mónica, Pereira Joana, Saraiva Fátima, Martins Hélia, Dores Hélder
Unidade Local de Saúde da Região de Leiria, E.P.E., 2410-197 Leiria, Portugal.
Palliative Care Team, Internal Medicine, Emergency and Intensive Care Department, Hospital da Luz, 1500-650 Lisbon, Portugal.
J Cardiovasc Dev Dis. 2025 Mar 6;12(3):94. doi: 10.3390/jcdd12030094.
Despite the multiple benefits of exercise for health, exercise in the presence of arrhythmic disorders can trigger adverse clinical events, including sudden cardiac death (SCD). The aim of this narrative review is to summarize the most recent recommendations regarding physical activity and exercise in individuals with Brugada Syndrome (BrS).
An advanced literature search was performed on the Pubmed and clinicaltrials.gov databases and published articles/clinical trials registered until September 2024 were analyzed. The final analysis included 33 articles.
Despite initial reports suggesting a higher risk of SCD in BrS, the risk is not as high as expected, and there is no evidence that exercise is an independent predictor. Therefore, scientific recommendations have become less restrictive. However, consensus on risk scores is lacking, making the evaluation of BrS a real challenge. The most recent recommendations emphasize individual evaluation, risk stratification, shared decision-making, and general preventive measures, allowing asymptomatic BrS patients as well as genotype positive/phenotype negative patients to participate in competitive sports, excluding sports under extreme conditions. Regarding patients with an implantable cardioverter defibrillator, both leisure and competitive sports may be considered in asymptomatic patients, avoiding contact sports.
Research on the relationship between exercise and cardiovascular disease is evolving, but evidence-based recommendations for sports in BrS patients are scarce and further studies are needed.
尽管运动对健康有诸多益处，但在存在心律失常疾病的情况下运动可能引发不良临床事件，包括心源性猝死（SCD）。本叙述性综述的目的是总结关于布加综合征（BrS）患者体育活动和运动的最新建议。
在Pubmed和clinicaltrials.gov数据库上进行了高级文献检索，并分析了截至2024年9月发表的文章/注册的临床试验。最终分析纳入了33篇文章。
尽管最初的报告表明BrS患者发生SCD的风险较高，但实际风险并不像预期的那么高，且没有证据表明运动是一个独立的预测因素。因此，科学建议的限制程度有所降低。然而，目前缺乏关于风险评分的共识，这使得BrS的评估成为一项真正的挑战。最新建议强调个体评估、风险分层、共同决策和一般预防措施，允许无症状的BrS患者以及基因型阳性/表型阴性患者参加竞技运动，但不包括极端条件下的运动。对于植入式心律转复除颤器患者，无症状患者可考虑进行休闲和竞技运动，但应避免接触性运动。
关于运动与心血管疾病关系的研究正在不断发展，但针对BrS患者运动的循证建议较少，仍需要进一步研究。
