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暴露于三唑类药物伊曲康唑的猪和公羊精子的氧化及分子结构改变

Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.

作者信息

Falero Cristian, Huanca Wilfredo, Barrios-Arpi Luis, Lira-Mejía Boris, Ramos-Coaguila Olger, Torres Edith, Ramos Eva, Romero Alejandro, Ramos-Gonzalez Mariella

机构信息

Zootecnia an Animal Production Laboratory, Faculty of Veterinary Medicine, Major National University of San Marcos, Lima 15021, Peru.

Reproduction Laboratory, Faculty of Veterinary Medicine, Major National University of San Marcos, Lima 15021, Peru.

出版信息

Toxics. 2025 Feb 28;13(3):176. doi: 10.3390/toxics13030176.

DOI:10.3390/toxics13030176
PMID:40137503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11945538/
Abstract

Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms. In the present study, the cytotoxic effect of the triazole ipconazole was evaluated in porcine and ram spermatozoa. Ipconazole significantly reduced sperm viability, increased ROS levels, altered catalase and SOD enzyme activity, and caused alterations in the molecular mRNA expression of structural biomarkers (PRM1, ODF2, AKAP4, THEG, SPACA3 and CLGN) related to fertility in males, as well as the overexpression of BAX (cell death) and ROMO1 (oxidative stress) mRNA. Our results indicate that the fungicide triazole is involved in cellular, enzymatic and molecular alteration of porcine and ram spermatozoa, and is possibly a factor in the development of infertility in male mammals.

摘要

三唑类农药在全球范围内广泛使用，但其滥用会对非靶标生物产生毒性作用。在本研究中，评估了三唑类农药抑霉唑对猪和公羊精子的细胞毒性作用。抑霉唑显著降低了精子活力，提高了活性氧水平，改变了过氧化氢酶和超氧化物歧化酶的活性，并导致与雄性生育力相关的结构生物标志物（PRM1、ODF2、AKAP4、THEG、SPACA3和CLGN）的分子mRNA表达发生改变，以及BAX（细胞死亡）和ROMO1（氧化应激）mRNA的过表达。我们的结果表明，杀菌剂三唑参与了猪和公羊精子的细胞、酶和分子改变，并且可能是雄性哺乳动物不育症发生发展的一个因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/522084f9825c/toxics-13-00176-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/f84177817ff3/toxics-13-00176-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/6f868854a4f4/toxics-13-00176-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/b05f39226104/toxics-13-00176-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/3a1bb122476b/toxics-13-00176-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/1effc5591c19/toxics-13-00176-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/73914ba1f891/toxics-13-00176-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/522084f9825c/toxics-13-00176-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/f84177817ff3/toxics-13-00176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/b65e2fe9e1b0/toxics-13-00176-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/6f868854a4f4/toxics-13-00176-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/b05f39226104/toxics-13-00176-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/3a1bb122476b/toxics-13-00176-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/1effc5591c19/toxics-13-00176-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/73914ba1f891/toxics-13-00176-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/067d/11945538/522084f9825c/toxics-13-00176-g008.jpg

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本文引用的文献

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2
Tebuconazole Induces Mouse Fetal Testes Damage via ROS Generation in an Organ Culture Method.三唑酮通过在器官培养方法中产生 ROS 诱导小鼠胎儿睾丸损伤。
Int J Mol Sci. 2024 Jun 27;25(13):7050. doi: 10.3390/ijms25137050.
3
Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures.
农药对人类健康和环境的影响及其作用机制与可能的应对措施。
Heliyon. 2024 Apr 4;10(7):e29128. doi: 10.1016/j.heliyon.2024.e29128. eCollection 2024 Apr 15.
4
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants.抗氧化防御系统应对氧化应激的几种途径：抗氧化酶、具有多种酶模拟活性的纳米材料和低分子量抗氧化剂。
Arch Toxicol. 2024 May;98(5):1323-1367. doi: 10.1007/s00204-024-03696-4. Epub 2024 Mar 14.
5
Oxidative Stress, Cytotoxic and Inflammatory Effects of Azoles Combinatorial Mixtures in Sertoli TM4 Cells.唑类组合混合物对睾丸支持细胞TM4的氧化应激、细胞毒性和炎症作用
Antioxidants (Basel). 2023 May 24;12(6):1142. doi: 10.3390/antiox12061142.
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Effects of cryopreservation in the presence of Natural Deep Eutectic Solvents (NADESs) on sperm parameters.在天然深共晶溶剂 (NADESs) 存在的情况下冷冻对精子参数的影响。
Cryobiology. 2023 Sep;112:104550. doi: 10.1016/j.cryobiol.2023.05.007. Epub 2023 May 23.
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Degradation strategies of pesticide residue: From chemicals to synthetic biology.农药残留的降解策略：从化学方法到合成生物学
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The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies.环境和职业因素对男性生育力的影响：人类研究的系统综述。
Andrology. 2022 Oct;10(7):1250-1271. doi: 10.1111/andr.13228. Epub 2022 Jul 18.
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