Han Jeong Su, Kim Hyeong Ho, Jeon Jae-Sik, Chung Yoo Na, Kim Jae Kyung
Department of Biomedical Laboratory Science, College of Health Sciences, Dankook University, Cheonan-si 31116, Republic of Korea.
Department of Medicine, College of Medicine, Dankook University, Cheonan-si 31116, Republic of Korea.
Pathogens. 2025 Mar 14;14(3):282. doi: 10.3390/pathogens14030282.
Influenza A is a respiratory virus that causes high infection rates and mortality worldwide, particularly affecting high-risk groups such as children, older adults, and individuals with chronic conditions. This retrospective study was conducted at a single tertiary hospital in Korea to analyze the epidemiological characteristics of influenza A infections from 2007 to 2024, focusing on age, sex, and seasonal variations. Using multiplex real-time PCR data from 23,284 individuals, we found that the overall positivity rate for influenza A was 5.6%, with seasonal fluctuations showing the highest rate in winter (14.0%) and the lowest in summer (0.5%). Age-based analysis revealed significantly higher positivity rates in older adults (7.9%) and adults (7.6%) than in children (5.0%) and infants (3.1%). No significant differences were observed in positivity rates between sexes (male: 5.43%, female: 5.76%, = 0.428). These findings provide essential insights into the regional and seasonal patterns of influenza A, emphasizing the importance of targeted vaccination strategies, adaptive public health interventions, and continuous surveillance for effective prevention and outbreak control management.
甲型流感是一种呼吸道病毒，在全球范围内导致高感染率和死亡率，尤其影响儿童、老年人和患有慢性病的个体等高风险群体。这项回顾性研究在韩国一家三级医院进行，旨在分析2007年至2024年甲型流感感染的流行病学特征，重点关注年龄、性别和季节变化。利用来自23284人的多重实时PCR数据，我们发现甲型流感的总体阳性率为5.6%，季节性波动显示冬季最高（14.0%），夏季最低（0.5%）。基于年龄的分析显示，老年人（7.9%）和成年人（7.6%）的阳性率显著高于儿童（5.0%）和婴儿（3.1%）。两性之间的阳性率未观察到显著差异（男性：5.43%，女性：5.76%，P = 0.428）。这些发现为甲型流感的区域和季节模式提供了重要见解，强调了针对性疫苗接种策略、适应性公共卫生干预措施以及持续监测对于有效预防和疫情控制管理的重要性。
