Curb J D, Borhani N O, Schnaper H, Kass E, Entwisle G, Williams W, Berman R
Am J Epidemiol. 1985 Mar;121(3):371-6. doi: 10.1093/oxfordjournals.aje.a114008.
The Hypertension Detection and Follow-up Program screened 34,012 individuals aged 60-69 years old in their homes in 14 communities around the United States during 1972 and 1973. The prevalence of hypertension, defined as diastolic blood pressure greater than or equal to 90 mmHg or on antihypertensive medication, was 42.1%. After a second clinic screen, 2,376 hypertensives were identified and randomized into Stepped Care, a special intensive treatment group, or Referred Care, a group referred to their usual medical care sources. These individuals were followed for five years (until they reached the ages of 65-74 years). Over the five years, 79.4% of older individuals remained under active care and 81.4% of those were at their goal diastolic blood pressure. Side-effects tended to be less frequent in older individuals than in younger ones. Older Stepped Care participants with mild hypertension (diastolic blood pressure 90-104 mmHg) had a 17.2% reduction in all-cause mortality over five years compared to Referred Care, which was primarily due to a reduction in deaths attributed to cardiovascular causes. Thus, antihypertensive treatment can be safely and beneficially administered to individuals in this age range with diastolic hypertension, including those with mild hypertension.
高血压检测与随访项目于1972年至1973年期间,在美国14个社区对34,012名60至69岁的老年人进行了上门筛查。高血压的定义为舒张压大于或等于90 mmHg或正在服用抗高血压药物,其患病率为42.1%。经过第二次门诊筛查,共识别出2376名高血压患者,并将他们随机分为阶梯治疗组(一种特殊强化治疗组)或转诊治疗组(转诊至其常规医疗服务机构的组)。这些个体被随访了五年(直到他们达到65至74岁)。在这五年中,79.4%的老年人仍在接受积极治疗,其中81.4%的人达到了舒张压目标。副作用在老年人中出现的频率往往低于年轻人。与转诊治疗组相比,患有轻度高血压(舒张压90至104 mmHg)的老年阶梯治疗参与者在五年内全因死亡率降低了17.2%,这主要是由于心血管原因导致的死亡减少。因此,对于这个年龄段的舒张期高血压患者,包括轻度高血压患者,可以安全且有益地进行抗高血压治疗。