Choi B C
Am J Epidemiol. 1985 May;121(5):737-43. doi: 10.1093/aje/121.5.737.
N-Nitroso compounds are known to be potent animal carcinogens. However, evidence of their effect on human cancers is inconclusive, and further investigations are needed. A mathematical model to create indices of nitrate, nitrite, and N-nitrosamine exposures, both exogenous and endogenous, is described in this paper. Estimation of the endogenous formation is based on the current knowledge of biochemistry and chemical kinetics of these compounds. The model can be applied to analyze data regarding the dietary history and use of tobacco products and alcoholic beverages obtained from epidemiologic questionnaires. Exposure levels of study and control subjects to these compounds can then be compared by conventional epidemiologic methods. This is an approach toward the combination of conventional epidemiologic methods and laboratory findings to study disease etiology.
已知N-亚硝基化合物是强效动物致癌物。然而，它们对人类癌症影响的证据尚无定论，需要进一步研究。本文描述了一个用于创建外源性和内源性硝酸盐、亚硝酸盐和N-亚硝胺暴露指数的数学模型。内源性形成的估计基于这些化合物的生物化学和化学动力学的现有知识。该模型可用于分析从流行病学调查问卷中获得的饮食史以及烟草制品和酒精饮料使用情况的数据。然后可以通过传统的流行病学方法比较研究对象和对照对象对这些化合物的暴露水平。这是一种将传统流行病学方法与实验室研究结果相结合来研究疾病病因的方法。
