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斯坦福A型主动脉夹层手术治疗与保守治疗的疗效:一项单中心回顾性研究

Outcomes of Surgical Versus Conservative Management in Stanford Type a Aortic Dissection: A Single-Center Retrospective Study.

作者信息

Eremia Irina-Anca, Popa Mihnea-Ioan-Gabriel, Anghel Cătălin-Alexandru, Stroe Teodora-Adriana, Eremia Eduard-Alexandru, Marinescu Andreea Nicoleta, Nica Remus Iulian, Nica Silvia

机构信息

Department of Family Medicine III, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Emergency Department, Emergency University Hospital Bucharest, 050098 Bucharest, Romania.

出版信息

Life (Basel). 2025 Mar 14;15(3):462. doi: 10.3390/life15030462.

Abstract

Acute aortic dissection (AAD) is a critical cardiovascular emergency marked by the rupture of the aortic intima, resulting in blood infiltration into the media and the formation of a false lumen. AAD incidence varies by area, emphasizing the need for better diagnostics and epidemiological investigations. Bucharest University Emergency Hospital's Emergency Department conducted this retrospective cohort analysis from May 2021 to May 2023. We examined 26 Stanford Type A aortic dissection patients to establish in-hospital mortality and one-year survival rates. The primary objective was to analyze demographic, clinical, and paraclinical factors and their impact on patient outcomes. A total of 57.7% of the study group was male and had a mean age of 58.2 years, and 69.2% of patients had hypertension, indicating its importance as a risk factor. Acute chest discomfort was reported by 53.8%, neurological problems by 30.8%, and syncope or hypotension by 42.3%. CT angiography and transthoracic echocardiogram (TTE) confirmed the diagnosis and assessed dissection severity. Pericardial effusion (19.2%) and moderate to severe aortic regurgitation (26.9%) were notable. Management varied by dissection intensity and location. Emergency surgery was performed in 61.5% of patients within 24 h of diagnosis, resulting in a 12.5% in-hospital death rate. Conservatively managed patients had a 60.0% in-hospital death rate. Timely intervention is crucial, since the surgical cohort had an 87.5% one-year survival rate compared to 30% for the conservatively managed cohort. Acute renal damage (25%), protracted mechanical ventilation (31.3%), and advanced supportive care infections were postoperative sequelae. Conservative care exacerbated visceral ischemia (20%) and heart failure (10%). Advanced age and hypotension upon admission were independent mortality predictors, emphasizing the need for early risk assessment and personalized treatment. Multimodal imaging, timely surgical referral, and excellent postoperative care improve AAD outcomes, according to this study.

摘要

急性主动脉夹层(AAD)是一种严重的心血管急症,其特征是主动脉内膜破裂,导致血液渗入中膜并形成假腔。AAD的发病率因地区而异,这凸显了更好的诊断和流行病学调查的必要性。布加勒斯特大学急诊医院急诊科于2021年5月至2023年5月进行了这项回顾性队列分析。我们检查了26例斯坦福A型主动脉夹层患者,以确定住院死亡率和一年生存率。主要目的是分析人口统计学、临床和辅助检查因素及其对患者预后的影响。研究组中57.7%为男性,平均年龄58.2岁,69.2%的患者患有高血压,表明其作为危险因素的重要性。53.8%的患者报告有急性胸痛,30.8%有神经系统问题,42.3%有晕厥或低血压。CT血管造影和经胸超声心动图(TTE)确诊并评估夹层严重程度。心包积液(19.2%)和中重度主动脉瓣反流(26.9%)较为显著。治疗方法因夹层强度和位置而异。61.5%的患者在诊断后24小时内接受了急诊手术,住院死亡率为12.5%。保守治疗的患者住院死亡率为60.0%。及时干预至关重要,因为手术组的一年生存率为87.5%,而保守治疗组为30%。急性肾损伤(25%)、长时间机械通气(31.3%)和晚期支持治疗感染是术后后遗症。保守治疗加剧了内脏缺血(20%)和心力衰竭(10%)。高龄和入院时低血压是独立的死亡预测因素,强调了早期风险评估和个性化治疗的必要性。根据这项研究,多模态成像、及时的手术转诊和出色的术后护理可改善AAD的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41ba/11943683/912ebcf977bf/life-15-00462-g001.jpg

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