Nikolic Dragan M, Latincic Stojan, Jevtovic Jelena, Gostiljac Drasko, Stojiljkovic Vesna, Jovanovic Snezana, Soldatovic Ivan
Faculty of Medicine, University of Belgrade, Dr Subotica 9, 11000 Belgrade, Serbia.
Clinic for Endocrinology, Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets, Dr Subotica 13, 11000 Belgrade, Serbia.
Life (Basel). 2025 Mar 15;15(3):468. doi: 10.3390/life15030468.
The aim of this study is to determine which types of microorganisms influence the onset and development of colorectal cancer (CRC) in humans.
In patients with CRC, three swabs were taken for microbiological analysis during surgical removal of the cancer: the first swab from the surface of the healthy intestinal mucosa, the second from the surface of the tumor, and the third from the middle of the tumor tissue.
In the healthy mucosa of the colon, the most prevalent microorganism was at 70.5%, followed by spp. (47.7%) and (20.5%). Microbiological analysis of the swabs from the surface of the tumor tissue showed that was the most prevalent at 72.7%, followed by spp. at 40.9%, at 25%, and at 20%. In the center of tumor tissue, was the most prevalent at 77.3%, followed by spp. at 47.7%, at 27%, and at 18.2%.
Certain types of bacteria can influence the emergence and development of cancer, while other types can suppress the development of tumor tissue. Microbiological analysis of human stool samples can prevent the development of CRC.
本研究的目的是确定哪些类型的微生物会影响人类结直肠癌（CRC）的发生和发展。
对于CRC患者，在手术切除癌症期间采集三份拭子进行微生物学分析：第一份拭子取自健康肠黏膜表面，第二份取自肿瘤表面，第三份取自肿瘤组织中部。
在结肠的健康黏膜中，最普遍的微生物是[具体微生物名称1]，占70.5%，其次是[具体微生物名称2]属（47.7%）和[具体微生物名称3]（20.5%）。对肿瘤组织表面拭子的微生物学分析表明，[具体微生物名称4]最为普遍，占72.7%，其次是[具体微生物名称2]属，占40.9%，[具体微生物名称5]占25%，[具体微生物名称6]占20%。在肿瘤组织中心，[具体微生物名称7]最为普遍，占77.3%，其次是[具体微生物名称2]属，占47.7%，[具体微生物名称5]占27%，[具体微生物名称6]占18.2%。
某些类型的细菌可影响癌症的发生和发展，而其他类型的细菌可抑制肿瘤组织的发展。对人类粪便样本进行微生物学分析可预防CRC的发生。
