Zhou Chengyan, Wang Guohao, Zhou Qingqing, Meng Fanzeng, Liu Shufang, Huang Jie, Dong Xuan
College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China.
State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Qingdao 266071, China.
Viruses. 2025 Mar 15;17(3):425. doi: 10.3390/v17030425.
Infectious precocity virus (IPV) poses a significant economic threat to the aquaculture industry by causing sexual precocity and slow growth in . In this study, we conducted an in-depth investigation into the genetic evolution of IPV from 2011 to 2024 by collecting 31 IPV variants through epidemiological surveys and public databases, including 29 variants with complete genomic sequences. The phylogenetic analysis revealed that these complete genomic sequences clustered into two distinct phylogenetic clades as follows: the Southeast Asian clade and the Chinese clade. Nucleotide and protein variation analyses demonstrated a high degree of similarity, with nucleotide identity ranging from 98.5% to 100% and protein identity from 99.4% to 100%. Further analysis of protein variations within the putative coding region identified two distinct variation patterns. The average dN/dS ratio of 0.12 highlights the strong purifying selection acting on IPV, particularly on structural proteins. In conclusion, this study significantly expands the genomic database of IPV and provides valuable insights into its genetic evolution. These findings offer critical scientific evidence to enhance detection protocols and support sustainable aquaculture practices.
传染性早熟病毒（IPV）通过导致性早熟和生长缓慢，对水产养殖业构成重大经济威胁。在本研究中，我们通过流行病学调查和公共数据库收集了31个IPV变体，对2011年至2024年期间IPV的遗传进化进行了深入研究，其中包括29个具有完整基因组序列的变体。系统发育分析表明，这些完整的基因组序列聚为两个不同的系统发育分支，即东南亚分支和中国分支。核苷酸和蛋白质变异分析显示出高度相似性，核苷酸同一性范围为98.5%至100%，蛋白质同一性范围为99.4%至100%。对推定编码区内蛋白质变异的进一步分析确定了两种不同的变异模式。平均dN/dS比值为0.12，突出了作用于IPV的强烈纯化选择，特别是对结构蛋白的选择。总之，本研究显著扩展了IPV的基因组数据库，并为其遗传进化提供了有价值的见解。这些发现为加强检测方案和支持可持续水产养殖实践提供了关键的科学证据。
