Rai Himani, Dhal Ipsita, Chowdhury Zachariah, Patel Swapnil, Pandey Durgatosh
Department of Onco-pathology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Varanasi, India.
Department of Surgical Oncology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Varanasi, India.
GHM Open. 2023 Aug 31;3(1):51-55. doi: 10.35772/ghmo.2023.01009.
Pulmonary sclerosing pneumocytoma (PSP), a rare benign lung tumor of primordial epithelial origin, commonly effects middle-aged Asian females. Diagnosis of this entity is challenging because of the non-specific radiological characteristics that resemble malignancies and its histological heterogeneity. Main differential diagnoses considered are adenocarcinoma lung and carcinoid tumor. In this case report, we discuss our experience of diagnosing a case of pulmonary sclerosing pneumocytoma, which showed increased SUV uptake in PET-CT indicating towards a malignancy and was also misdiagnosed as adenocarcinoma in CT-guided FNAC. The histology showed variable morphological features and there was a differential staining pattern of TTF1 and napsin A in the cells. We have highlighted the differential diagnosis and the challenges faced for diagnosing this benign, rare entity.
肺硬化性细胞瘤(PSP)是一种罕见的起源于原始上皮的良性肺肿瘤,常见于中年亚洲女性。由于其具有类似于恶性肿瘤的非特异性放射学特征及其组织学异质性,该实体的诊断具有挑战性。主要考虑的鉴别诊断是肺腺癌和类癌肿瘤。在本病例报告中,我们讨论了诊断一例肺硬化性细胞瘤的经验,该病例在PET-CT中显示SUV摄取增加,提示为恶性肿瘤,并且在CT引导下细针穿刺活检(FNAC)中也被误诊为腺癌。组织学显示出可变的形态特征,细胞中TTF1和 napsin A存在不同的染色模式。我们强调了鉴别诊断以及诊断这种良性罕见实体所面临的挑战。