Gupta Vishakha, Rastogi Pavitra, Ajay Sadhna, Lal Nand, Verma Umesh Pratap, Singhal Rameshwari, Pathak Anjani Kumar, Nigam Nitu, Rastogi Paridhi
Department of Periodontology, Faculty of Dental Science, King George Medical University, 5th Floor, New Dental Building, Lucknow, U.P, 226003, India.
Department of Biochemistry, Autonomous State Medical College, 2nd Floor, Academic block, Jaunpur, U.P, 222001, India.
J Oral Biol Craniofac Res. 2025 May-Jun;15(3):493-499. doi: 10.1016/j.jobcr.2025.02.013. Epub 2025 Mar 11.
Zinc is an essential micronutrient that plays a crucial role in maintaining oral health. Periodontitis is a widespread oral disease characterized by inflammation and destruction of the gums and surrounding tissues. The objective of this study was to evaluate the effect of oral zinc supplementation as an adjunct to scaling and root planing in the treatment of periodontitis by evaluating its effects on clinical parameters and salivary MMP-8 level.
42 patients were enrolled in the study from the periodontology OPD of a tertiary care hospital in India. The subjects were divided into two groups: group 1 and group 2 consisting of 21 patients each of moderate to severe periodontitis. Group 1 was given oral zinc supplementation along with scaling and root planing (SRP) and group 2 was given placebo tablet along with SRP for 1 month. Several periodontal parameters were assessed, including Papillary bleeding Index (BI), Gingival index (GI), Probing pocket depth (PPD) and Clinical attachment level (CAL) at baseline as well as at 1 month post treatment. Around 3 ml of whole unstimulated saliva was collected for MMP-8 estimation by ELISA method at baseline as well as at 1 month.
The data was analyzed using SPSS version 26. All clinical parameters and MMP-8 level in saliva were comparable at baseline. 1 month after respective treatment modalities were performed in each group, it was found that all clinical parameters and salivary MMP-8 level showed significant differences with group 1 (zinc + SRP) showing highly significant decrease in GI, PPD and CAL (p < 0.01) and significant decrease in BI and salivary MMP-8 level when compared to group 2 (placebo + SRP) (p < 0.05).
When compared with scaling and root planing alone, the administration of oral zinc supplementation along with scaling and root planing showed greater reduction in clinical parameters and salivary MMP-8 levels in patients with moderate to severe periodontitis. Zinc has a positive effect in management of periodontitis and can serve as an easy, cost effective, harmless and beneficial adjunct in treatment of periodontitis.
锌是一种必需的微量营养素，在维持口腔健康方面起着至关重要的作用。牙周炎是一种常见的口腔疾病，其特征是牙龈和周围组织的炎症和破坏。本研究的目的是通过评估口服补充锌对临床参数和唾液MMP - 8水平的影响，来评价口服补充锌作为龈下刮治和根面平整辅助治疗牙周炎的效果。
从印度一家三级护理医院的牙周病门诊招募了42名患者。受试者分为两组：第1组和第2组，每组各有21名中度至重度牙周炎患者。第1组在接受龈下刮治和根面平整（SRP）的同时给予口服锌补充剂，第2组在接受SRP的同时给予安慰剂片，为期1个月。评估了几个牙周参数，包括基线时以及治疗后1个月时的乳头出血指数（BI）、牙龈指数（GI）、探诊深度（PPD）和临床附着水平（CAL）。在基线时以及1个月时，通过ELISA法收集约3ml未刺激的全唾液用于MMP - 8测定。
使用SPSS 26版对数据进行分析。所有临床参数和唾液中的MMP - 8水平在基线时具有可比性。在每组进行各自的治疗方式1个月后，发现所有临床参数和唾液MMP - 8水平均存在显著差异，与第2组（安慰剂 + SRP）相比，第1组（锌 + SRP）的GI、PPD和CAL显著降低（p < 0.01），BI和唾液MMP - 8水平也显著降低（p < 0.05）。
与单独进行龈下刮治和根面平整相比，口服补充锌联合龈下刮治和根面平整在中度至重度牙周炎患者中显示出临床参数和唾液MMP - 8水平的更大降低。锌在牙周炎的治疗中具有积极作用，可作为治疗牙周炎的一种简便、经济有效、无害且有益的辅助手段。
