Suvarna Chintada, Chaitanya Nallan Csk, Ameer Shaik, Mannava Himabindu, Bontala Parinita, Alyami Jabar Sadan, Samreen Humaira, Kondapaneni Jayasurya
Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.
Department of Oral Medicine and Radiology, Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India.
Int J Appl Basic Med Res. 2020 Jan-Mar;10(1):54-58. doi: 10.4103/ijabmr.IJABMR_138_19. Epub 2020 Jan 3.
Lichen planus is a T-cell-mediated autoimmune disease, in which CD8+ T-cells releases the cytokines such as tumor necrosis factor-alpha and interleukin-12 disrupting basement membrane integrity. Treatment modalities were directed toward the relief in signs and symptoms and preventing recurrences. Zinc activates caspase-3 and DNA fragmentation, resulting in the apoptosis of keratinocytes. Prevention of matrix metalloproteinases1 (MMP1) activation, inhibits the Tcell accumulation in oral lichen planus (OLP) and by inhibiting MMP9, prevents the cleavage of collagen resulting in maintaining the integrity of the basement membrane.
The main objective of the study is to compare the efficacy of oral zinc 50 mg and 0.1% triamcinolone Orabase with 0.1% triamcinolone Orabase alone on the healing process of symptomatic OLP.
A total of forty participants were randomly categorized into two groups: Group A and Group B with 20 patients with OLP and having symptoms of burning sensation. Group A patients had received 0.1% triamcinolone Orabase twice daily application. Group B patients had provided with oral zinc 50 mg and 0.1% triamcinolone Orabase twice daily for 8 weeks. The follow-up period for both the groups was 6 months. Lesional size was measured by Thongprasom scale and burning sensation was assessed by visual analog scale at each visit till the cessation of treatment.
There was decrease in the burning sensation and lesional size from the first visit to follow-up period which was statistically significant in both groups ( = 0.000).
Oral zinc therapy was adjunctive in reducing the burning sensation and lesional size in the symptomatic OLP.
扁平苔藓是一种T细胞介导的自身免疫性疾病，其中CD8 + T细胞释放细胞因子，如肿瘤坏死因子-α和白细胞介素-12，破坏基底膜完整性。治疗方式旨在缓解体征和症状并预防复发。锌可激活半胱天冬酶-3并导致DNA片段化，从而引起角质形成细胞凋亡。预防基质金属蛋白酶1（MMP1）的激活，可抑制口腔扁平苔藓（OLP）中T细胞的积聚，并且通过抑制MMP9，可防止胶原蛋白的裂解，从而维持基底膜的完整性。
本研究的主要目的是比较口服50毫克锌和0.1%曲安奈德口腔糊剂联合0.1%曲安奈德口腔糊剂单独使用对有症状的OLP愈合过程的疗效。
总共40名参与者被随机分为两组：A组和B组，每组20名有OLP且有烧灼感症状的患者。A组患者每天两次使用0.1%曲安奈德口腔糊剂。B组患者每天两次服用50毫克口服锌和0.1%曲安奈德口腔糊剂，持续8周。两组的随访期均为6个月。每次就诊时，直至治疗结束，用通普拉松量表测量病损大小，用视觉模拟量表评估烧灼感。
从首次就诊到随访期，烧灼感和病损大小均有所降低，两组在统计学上均有显著差异（P = 0.000）。
口服锌疗法在减轻有症状的OLP的烧灼感和病损大小方面具有辅助作用。
