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用于细胞外囊泡治疗效果的微环境调节

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles.

作者信息

Xiang Bilu, Zhang Shiying, Zhao Irene Shuping, Gan Xueqi, Zhang Yang

机构信息

School of Dentistry, Shenzhen University Medical School, Shenzhen, 518055, China.

Institute of Oral Science, Shenzhen University, Shenzhen, 518055, China.

出版信息

Adv Sci (Weinh). 2025 May;12(18):e2503027. doi: 10.1002/advs.202503027. Epub 2025 Mar 27.

DOI:10.1002/advs.202503027
PMID:40145773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12079496/
Abstract

Extracellular vesicles (EVs) hold significant promise for the prevention and treatment of various diseases. However, the translation of EV-based therapies into clinical practice faces considerable challenges, particularly in terms of production yield and therapeutic efficacy. Recent studies have emphasized the heterogeneity of EVs and the influence of parental cell microenvironmental signals on their biogenesis, cargo composition, and therapeutic outcomes. This review offers a comprehensive overview of strategies to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation. Additionally, it explores how microenvironmental signals affect EV cargoes and the mechanisms by which these signals can improve therapeutic efficacy. The review also addresses current challenges and potential solutions to accelerate the clinical translation of EV therapies. Ultimately, it highlights the potential of microenvironmental modulation in unlocking the full therapeutic capacity of EVs, providing key insights into their production and clinical use for treating various diseases.

摘要

细胞外囊泡（EVs）在预防和治疗各种疾病方面具有巨大潜力。然而，将基于EVs的疗法转化为临床实践面临着相当大的挑战，尤其是在产量和治疗效果方面。最近的研究强调了EVs的异质性以及亲代细胞微环境信号对其生物发生、货物组成和治疗结果的影响。本综述全面概述了通过物理、生化和机械调节来优化EVs治疗效果的策略。此外，它还探讨了微环境信号如何影响EVs货物以及这些信号提高治疗效果的机制。该综述还讨论了当前的挑战和潜在解决方案，以加速EVs疗法的临床转化。最终，它强调了微环境调节在释放EVs全部治疗能力方面的潜力，为其生产和治疗各种疾病的临床应用提供了关键见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/c7506f298fef/ADVS-12-2503027-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/4561144bb828/ADVS-12-2503027-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/90b77b7a0fd5/ADVS-12-2503027-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/53075edec558/ADVS-12-2503027-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/b4813aa2a797/ADVS-12-2503027-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/78e950ac7b27/ADVS-12-2503027-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/c7506f298fef/ADVS-12-2503027-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/4561144bb828/ADVS-12-2503027-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/90b77b7a0fd5/ADVS-12-2503027-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/53075edec558/ADVS-12-2503027-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/b4813aa2a797/ADVS-12-2503027-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/78e950ac7b27/ADVS-12-2503027-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49d0/12079496/c7506f298fef/ADVS-12-2503027-g005.jpg

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Harnessing genetically engineered cell membrane-derived vesicles as biotherapeutics.利用基因工程改造的细胞膜衍生囊泡作为生物疗法。
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New insights of engineered extracellular vesicles as promising therapeutic systems.
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4
Harnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications.利用细胞外囊泡的异质性进行诊断和治疗应用。
Nat Nanotechnol. 2025 Jan;20(1):14-25. doi: 10.1038/s41565-024-01774-3. Epub 2024 Oct 28.
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