Mirmosayyeb Omid, Vaheb Saeed, Mohammadi Ida, Alinejadfard Mohammadreza, Yazdan Panah Mohammad, Rajai Firouzabadi Shahryar, Shaygannejad Vahid
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Eur J Med Res. 2025 Apr 17;30(1):299. doi: 10.1186/s40001-025-02533-3.
Cognitive impairment (CI) is prevalent among people with multiple sclerosis (PwMS), significantly affecting their quality of life and functional capacity. While the relationship between CI and motor function has been explored in healthy aging and other neurological conditions, its association with upper and lower motor function in PwMS remains underexplored.
This cross-sectional study analyzed data from 125 PwMS (M: 37.6 years; median disease duration: 8 years) to examine cognitive outcomes. Cognitive status was evaluated using the Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-Second Edition (CVLT-II), and Brief Visuospatial Memory Test-Revised (BVMT-R). Motor function was assessed with the 9-Hole Peg Test (9-HPT) and the Timed 25-Foot Walk Test (T25FW). Hierarchical regression models identified significant predictors of cognitive performance.
Multivariate analyses revealed that T25FW was the strongest predictor of SDMT (β = - 3.10, p < 0.001), CVLT-II (β = - 2.91, p < 0.001), and BVMT-R (β = - 1.98, p < 0.001). Additional predictors included disease duration (SDMT: β = - 0.26, p = 0.033; CVLT-II: β = - 0.28, p = 0.048; BVMT-R: β = - 0.23, p = 0.037) and education (BVMT-R: β = 0.60, p = 0.004). EDSS was a significant predictor for SDMT (β = - 1.42, p = 0.029). The 9-HPT was not independently associated with cognitive status.
T25FW emerged as a robust predictor of processing speed, verbal memory, and visuospatial memory, underscoring its value as a practical assessment tool correlating with cognitive status in PwMS.
认知障碍（CI）在多发性硬化症患者（PwMS）中普遍存在，严重影响他们的生活质量和功能能力。虽然在健康老龄化和其他神经系统疾病中已经探讨了CI与运动功能之间的关系，但在PwMS中其与上下运动功能的关联仍未得到充分研究。
这项横断面研究分析了125名PwMS患者（男性：37.6岁；疾病持续时间中位数：8年）的数据，以检查认知结果。使用符号数字模态测试（SDMT）、加利福尼亚言语学习测试第二版（CVLT-II）和修订版简短视觉空间记忆测试（BVMT-R）评估认知状态。用9孔插板测试（9-HPT）和25英尺定时步行测试（T25FW）评估运动功能。分层回归模型确定了认知表现的显著预测因素。
多变量分析显示，T25FW是SDMT（β = -3.10，p < 0.001）、CVLT-II（β = -2.91，p < 0.001）和BVMT-R（β = -1.98，p < 0.001）的最强预测因素。其他预测因素包括疾病持续时间（SDMT：β = -0.26，p = 0.033；CVLT-II：β = -0.28，p = 0.048；BVMT-R：β = -0.23，p = 0.037）和教育程度（BVMT-R：β = 0.60，p = 0.004）。扩展残疾状态量表（EDSS）是SDMT的显著预测因素（β = -1.42，p = 0.029）。9-HPT与认知状态无独立关联。
T25FW是处理速度、言语记忆和视觉空间记忆的有力预测因素，突出了其作为与PwMS认知状态相关的实用评估工具的价值。
