三种不同纳米颗粒改性的3D打印义齿树脂的抗菌效果：一项研究。

Antimicrobial Effect of Three Different Nanoparticles-Modified 3D-Printed Denture Resin: An Study.

作者信息

Abd Elhamid Abo Salh Islam Basuny, Add El-Salam Emad Boriqaa, Ezzat Amgad A, Aboshama Mohamed, Elhagali Ahmed Fathey

机构信息

Department of Removable Prosthodontics, Faculty of Dental Medicine, Al-Azhar University, Assiut, Egypt.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.

出版信息

J Int Soc Prev Community Dent. 2025 Feb 26;15(1):42-49. doi: 10.4103/jispcd.jispcd_53_24. eCollection 2025 Jan-Feb.

DOI:10.4103/jispcd.jispcd_53_24

PMID:40151552

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11940513/

Abstract

AIM

This study aimed to determine the antibacterial effectiveness of adding zirconia nanoparticles (NPs; ZrONPs), silver NPs (AgNPs), and titanium dioxide NPs (TiONPs) in various concentrations to three-dimensional (3D)-printed denture resin against , , and , this study was carried out.

MATERIALS AND METHODS

The antimicrobial efficacy of 150 disk-shaped specimens with a diameter of 15 mm × 2 mm of unmodified ( = 15) and modified ( = 135) 3D-printed denture resin specimens after the addition of silanated ZrONPs, AgNPs, or TiONPs ( = 45) in varying concentrations ( = 15) of 0.5%, 1%, and 1.5% were compared using three oral bacteria (, , and ) as test subjects. Antimicrobial activity was tested by disk diffusion methods.

RESULTS

According to the results, when the three tested NPs (ZrONPs, AgNPs, and TiONPs) were added, the bacterial count significantly decreased compared with the unmodified 3D-printed resin. Additionally, the findings showed that as the concentration of the studied NPs increased, so did their antibacterial activity. At 1.5% and 1% concentrations, the AgNPs' antibacterial activity was negligible. However, the study's findings showed that, in terms of the kinds of microorganisms studied, there were no appreciable variations between the three tested NPs.

CONCLUSION

The inclusion of ZrONPs, AgNPs, and TiONPs significantly had antimicrobial action against (, , and ).

摘要

目的

本研究旨在确定在三维（3D）打印义齿树脂中添加不同浓度的氧化锆纳米颗粒（ZrONPs）、银纳米颗粒（AgNPs）和二氧化钛纳米颗粒（TiONPs）对[具体细菌名称1]、[具体细菌名称2]和[具体细菌名称3]的抗菌效果，从而开展了本研究。

材料与方法

使用三种口腔细菌（[具体细菌名称1]、[具体细菌名称2]和[具体细菌名称3]）作为测试对象，比较了150个直径为15毫米×2毫米的圆盘形标本的抗菌效果，这些标本包括未改性的（n = 15）和改性的（n = 135）3D打印义齿树脂标本，其中改性标本添加了硅烷化的ZrONPs、AgNPs或TiONPs（n = 45），浓度分别为0.5%、1%和1.5%（n = 15）。通过纸片扩散法测试抗菌活性。

结果

结果显示，添加三种测试纳米颗粒（ZrONPs、AgNPs和TiONPs）后，与未改性的3D打印树脂相比，细菌数量显著减少。此外，研究结果表明，随着所研究纳米颗粒浓度的增加，其抗菌活性也增强。在1.5%和1%的浓度下AgNPs的抗菌活性可忽略不计。然而，该研究结果表明，在所研究的微生物种类方面，三种测试纳米颗粒之间没有明显差异。