痛风患者极低密度脂蛋白C载脂蛋白异常的证明。
Demonstration of an abnormality of C apoprotein of very low density lipoprotein in patients with gout.
作者信息
Macfarlane D G, Midwinter C A, Dieppe P A, Bolton C H, Hartog M
出版信息
Ann Rheum Dis. 1985 Jun;44(6):390-4. doi: 10.1136/ard.44.6.390.
The very low density (VLDL) apolipoproteins of 12 male patients with gout have been studied by analytical isoelectric focusing. The relative percentage distribution of the C apolipoproteins was calculated and compared with that from 12 normolipidaemic and 12 'lipid-matched' controls. In the gout patients apolipoprotein CII (apo CII) represented 19.6% of the VLDL C proteins and the CII/CIII2 ratio was 0.57. In the normolipidaemic controls apo CII represented 28.8% and in the lipid-matched controls 33.1% of VLDL apo C, and the CII/CIII2 ratio approached one in each control group. These differences were significant. This suggests that a reduction in VLDL apo CII may predispose to the hypertriglyceridaemia that is commonly found in patients with gout.
采用分析等电聚焦法对12例男性痛风患者的极低密度脂蛋白（VLDL）载脂蛋白进行了研究。计算了载脂蛋白C的相对百分比分布，并与12例血脂正常者及12例“血脂匹配”的对照者进行了比较。痛风患者中，载脂蛋白CII（apo CII）占VLDL C蛋白的19.6%，CII/CIII2比值为0.57。在血脂正常的对照组中，apo CII占VLDL载脂蛋白C的28.8%，在血脂匹配的对照组中占33.1%，且每个对照组的CII/CIII2比值均接近1。这些差异具有统计学意义。这表明VLDL apo CII减少可能易导致痛风患者常见的高甘油三酯血症。
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