Marcus J, Hans S L, Mednick S A, Schulsinger F, Michelsen N
Arch Gen Psychiatry. 1985 Aug;42(8):753-61. doi: 10.1001/archpsyc.1985.01790310015002.
Neurological functioning was compared in children at risk for schizophrenia from samples recruited in Israel and Denmark. In both samples neurological signs were assessed in school-age children with one schizophrenic parent and a matched group of children with no mentally ill parents. Multidimensional Scalogram Analysis of data identified, in both samples, a radex structure of neurological functioning, radiating from motor to sensory-perceptual signs. In both samples, the gradient of neurological functioning differed between the offspring of schizophrenics and controls. For both the offspring of schizophrenics and controls, the largest number of children showed no or few signs of neurological dysfunctioning. A subgroup of the offspring of schizophrenics, but not the controls, showed multiple signs of neurological dysfunctioning that varied in pattern among individuals.
对从以色列和丹麦招募的样本中患精神分裂症风险较高的儿童的神经功能进行了比较。在这两个样本中，对有一位精神分裂症父母的学龄儿童以及一组匹配的无精神疾病父母的儿童进行了神经体征评估。对数据进行的多维量表分析在两个样本中都确定了神经功能的辐射状结构，从运动体征辐射到感觉-知觉体征。在两个样本中，精神分裂症患者后代与对照组之间神经功能的梯度有所不同。对于精神分裂症患者的后代和对照组来说，大多数儿童没有或只有很少的神经功能障碍迹象。精神分裂症患者后代中有一个亚组出现了多种神经功能障碍迹象，个体之间的模式各不相同，但对照组没有。
