Gillberg C, Terenius L, Lönnerholm G
Arch Gen Psychiatry. 1985 Aug;42(8):780-3. doi: 10.1001/archpsyc.1985.01790310042005.
Twenty 2- to 13-year-old infantile autistic children (16 boys and four girls) and four 4- to 13-year-old children (two boys and two girls) with other kinds of childhood psychoses were compared with eight 6-month-old to 6-year-old normal children with regard to cerebrospinal fluid contents of endorphin fractions I and II. The psychosis groups showed higher mean cerebrospinal fluid endorphin fraction II levels, and 11 (55%) of the 20 autistic patients showed values higher than the highest in the group of normal children. There was a trend toward a correlation between high fraction II levels and self-destructiveness and decreased pain sensibility in the psychotic children. The results are regarded as preliminary but as warranting further research in this potentially fruitful field.
将20名2至13岁的婴儿自闭症儿童（16名男孩和4名女孩）以及4名4至13岁患有其他类型儿童期精神病的儿童（2名男孩和2名女孩）与8名6个月至6岁的正常儿童在脑脊液中内啡肽I和II组分的含量方面进行了比较。精神病组的脑脊液内啡肽II组分平均水平较高，20名自闭症患者中有11名（55%）的值高于正常儿童组中的最高值。在患有精神病的儿童中，较高的II组分水平与自我毁灭行为和疼痛敏感性降低之间存在相关趋势。这些结果被视为初步的，但值得在这个可能富有成果的领域进行进一步研究。
