Lindström L H, Widerlöv E, Gunne L M, Wahlström A, Terenius L
Acta Psychiatr Scand. 1978 Feb;57(2):153-64. doi: 10.1111/j.1600-0447.1978.tb06883.x.
The significance of endorphins, endogenous morphine-like agents, in some psychiatric disorders was investigated. Samples of cerebrospinal fluid were taken by lumbar puncture from healthy volunteers and from patients with schizophrenic, manic-depressive and puerperal psychosis and analyzed for two major fractions of endorphins (Fractions I and II). In 19 healthy volunteers the levels of the two fractions fell within a fairly narrow range. In contrast, six out of nine drug-free and symptom-rich schizophrenics showed elevated levels of Fraction I, which returned to normal or slightly supranormal values after treatment with neuroleptics or propranolol. This decrement was paralleled by a clinical improvement in four of six responding patients. In four manic-depressive patients, serial samples of cerebrospinal fluid revealed elevated endorphin levels, particularly Fraction I during the manic stage. In three out of four patients with puerperal psychosis, the levels of endorphins (either Fraction I or II) were elevated in the acute drug-free stage. During a later symptom-free stage, after treatment with ECT and/or neuroleptics, the endorphin levels were within the normal range. The present data lend credit to the hypothesis that endorphins are involved in some psychotic states in the human.
对内啡肽（一种内源性吗啡样物质）在某些精神疾病中的意义进行了研究。通过腰椎穿刺从健康志愿者以及患有精神分裂症、躁狂抑郁症和产褥期精神病的患者身上采集脑脊液样本，并分析内啡肽的两个主要组分（组分I和组分II）。在19名健康志愿者中，这两个组分的水平落在相当窄的范围内。相比之下，9名未用药且症状明显的精神分裂症患者中有6名显示组分I水平升高，在用抗精神病药物或普萘洛尔治疗后恢复到正常或略高于正常的值。在6名有反应的患者中有4名临床症状改善与这种下降同时出现。在4名躁狂抑郁症患者中，脑脊液的系列样本显示内啡肽水平升高，尤其是在躁狂阶段的组分I。在4名产褥期精神病患者中有3名，在急性未用药阶段内啡肽（组分I或组分II）水平升高。在随后的无症状阶段，经电休克治疗和/或抗精神病药物治疗后，内啡肽水平在正常范围内。目前的数据支持内啡肽参与人类某些精神状态的假说。
