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基于人群的成年系统性红斑狼疮队列中社区活动受限的患病率及其相关因素。

Prevalence and correlates of restricted community mobility in a population-based cohort of adults with systemic lupus erythematosus.

作者信息

Milanfar Leila, Bowling Christopher Barrett, Hoge Courtney, Eudy Amanda, Katz Patricia, Yazdany Jinoos, Plantinga Laura

机构信息

University of California San Francisco, San Francisco, California, USA.

Duke University, Durham, North Carolina, USA.

出版信息

Lupus Sci Med. 2025 Mar 28;12(1):e001430. doi: 10.1136/lupus-2024-001430.

Abstract

OBJECTIVE

Restrictions in community mobility, defined as the frequency of and help required to travel to 'life-spaces' (bedroom, home, yard, neighbourhood and town), are associated with poor outcomes among older adults. We aimed to describe and explore factors associated with community mobility among adults with SLE.

METHODS

We assessed community mobility cross-sectionally in a population-based SLE cohort (October 2019 to May 2022), using the University of Alabama Birmingham Study of Aging Life-Space Assessment (UAB LSA) (score range, 0-120; higher scores=greater community mobility). Community mobility was considered to be restricted if the individual reported not reaching the neighbourhood life-space or beyond at least weekly and without help. Estimated percentages (95% CIs) with restricted community mobility were assessed with multivariable logistic regression adjusting for demographics and disease activity and damage.

RESULTS

Among 447 participants (91.7% women; 82.6% Black; mean age 46.2; mean UAB LSA score 53.6), 41.6% had restricted community mobility. After adjustment, Black versus White race (43.4% (95% CI 38.5% to 48.2%) vs 24.4% (12.7% to 36.2%)), lowest versus highest educational attainment (51.1% (41.4% to 60.7%) vs 27.2% (20.7% to 33.6%)) and higher versus lower disease activity (55.2% (48.4% to 62.0%) vs 28.5% (22.9% to 34.3%)) were associated with a higher prevalence of restricted community mobility; there were no differences by age, sex or disease damage.

CONCLUSION

Restricted community mobility was common among adults with SLE, and Black race, lower education and high disease activity were associated with more restricted community mobility. Further research to understand the association of community mobility with outcomes and implement strategies to improve community mobility in people with SLE is warranted.

摘要

目的

社区活动能力受限定义为前往“生活空间”(卧室、家中、院子、社区和城镇)的出行频率及所需帮助,与老年人不良预后相关。我们旨在描述和探究系统性红斑狼疮(SLE)成年患者社区活动能力相关因素。

方法

我们在一项基于人群的SLE队列研究(2019年10月至2022年5月)中对社区活动能力进行横断面评估,采用阿拉巴马大学伯明翰分校衰老生活空间评估研究(UAB LSA)(评分范围0 - 120;分数越高 = 社区活动能力越强)。如果个体报告至少每周无法在无帮助的情况下到达社区生活空间或更远的地方,则认为社区活动能力受限。采用多变量逻辑回归对人口统计学、疾病活动度和损伤进行调整,评估社区活动能力受限的估计百分比(95%置信区间)。

结果

在447名参与者中(91.7%为女性;82.6%为黑人;平均年龄46.2岁;UAB LSA平均评分为53.6),41.6%的人社区活动能力受限。调整后,黑人与白人种族(43.4%(95%置信区间38.5%至48.2%)对24.4%(12.7%至36.2%))、最低与最高教育程度(51.1%(41.4%至60.7%)对27.2%(20.7%至33.6%))以及较高与较低疾病活动度(55.2%(48.4%至62.0%)对28.5%(22.9%至34.3%))与社区活动能力受限的较高患病率相关;年龄、性别或疾病损伤方面无差异。

结论

社区活动能力受限在SLE成年患者中很常见,黑人种族、低教育程度和高疾病活动度与更受限的社区活动能力相关。有必要进一步开展研究以了解社区活动能力与预后的关联,并实施改善SLE患者社区活动能力的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17cb/11956307/59142390f41f/lupus-12-1-g001.jpg

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