Ribeiro Catarina Gil, Pimentel Alice, Lages Rita, Ferreira Ana Isabel, da Silva João Barros
Departamento de Cirurgia de ULS Tâmega e Sousa, Penafiel, Portugal.
Departamento de Cirurgia de ULS Tâmega e Sousa, Penafiel, Portugal.
Int J Surg Case Rep. 2025 Apr;129:111222. doi: 10.1016/j.ijscr.2025.111222. Epub 2025 Mar 27.
Idiopathic granulomatous mastitis (IGM) is a rare, benign, and chronic inflammatory breast disease with unclear etiology and no standardized treatment. It often presents as a painful breast mass that mimics breast cancer, necessitating thorough diagnostic evaluation.
This report discusses a case of a 39-year-old pregnant woman with IGM associated with erythema nodosum, a poorly understood co-occurrence. Initial treatment included antibiotics and surgical drainage for an abscess. Despite multiple interventions, including corticosteroids and methotrexate, the disease persisted with recurrent episodes.
This case underscores the complexities of managing IGM, highlighting its association with systemic manifestations such as erythema nodosum. Current therapeutic approaches range from conservative management to immunosuppressive therapy and surgery, with outcomes varying widely.
Further studies are needed to elucidate the pathophysiology and establish optimal treatment strategies for IGM, particularly in the context of systemic involvement.
特发性肉芽肿性乳腺炎（IGM）是一种罕见的、良性的慢性炎症性乳腺疾病，病因不明，且无标准化治疗方法。它常表现为疼痛性乳腺肿块，酷似乳腺癌，因此需要进行全面的诊断评估。
本报告讨论了一例39岁的孕妇，患有与结节性红斑相关的IGM，这种同时出现的情况了解甚少。初始治疗包括针对脓肿使用抗生素和手术引流。尽管进行了多种干预措施，包括使用皮质类固醇和甲氨蝶呤，但疾病仍持续发作。
该病例突显了管理IGM的复杂性，强调了其与结节性红斑等全身表现的关联。目前的治疗方法从保守管理到免疫抑制治疗和手术不等，结果差异很大。
需要进一步研究以阐明IGM的病理生理学，并建立最佳治疗策略，特别是在存在全身受累的情况下。
