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GDF-15 blockade: A multi-directional approach to potentiate cancer immunotherapy and alleviate cancer cachexia.

作者信息

Melero Ignacio, Klar Kathrin, Leo Eugen

机构信息

Clinica Universidad de Navarra, CIMA, IDISNA and CIBERONC, Pamplona, Spain, and, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Clinical Development, CatalYm GmbH, Martinsried, Germany.

出版信息

Clin Transl Med. 2025 Apr;15(4):e70280. doi: 10.1002/ctm2.70280.

DOI:10.1002/ctm2.70280
PMID:40159463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11955301/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3df5/11955301/ec5a5a375bfb/CTM2-15-e70280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3df5/11955301/ec5a5a375bfb/CTM2-15-e70280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3df5/11955301/ec5a5a375bfb/CTM2-15-e70280-g001.jpg

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本文引用的文献

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Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours.中和生长分化因子-15(GDF-15)可克服实体瘤中抗程序性死亡蛋白1(anti-PD-1)和抗程序性死亡配体1(anti-PD-L1)的耐药性。
Nature. 2025 Jan;637(8048):1218-1227. doi: 10.1038/s41586-024-08305-z. Epub 2024 Dec 11.
2
GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models.GB18-06,一种针对 GDF15 的纳米抗体,可有效缓解恶病质模型中的体重减轻并恢复身体机能。
MAbs. 2024 Jan-Dec;16(1):2416453. doi: 10.1080/19420862.2024.2416453. Epub 2024 Oct 14.
3
Ponsegromab for the Treatment of Cancer Cachexia.
泊塞格单抗用于治疗癌症恶病质。
N Engl J Med. 2024 Dec 19;391(24):2291-2303. doi: 10.1056/NEJMoa2409515. Epub 2024 Sep 14.
4
Overview of growth differentiation factor 15 (GDF15) in metabolic diseases.生长分化因子15(GDF15)在代谢性疾病中的概述
Biomed Pharmacother. 2024 Jul;176:116809. doi: 10.1016/j.biopha.2024.116809. Epub 2024 May 29.
5
Cancer Cachexia: New Insights and Future Directions.癌症恶病质:新见解与未来方向
Cancers (Basel). 2023 Nov 26;15(23):5590. doi: 10.3390/cancers15235590.
6
Molecular basis of GDF15 induction and suppression by drugs in cardiomyocytes and cancer cells toward precision medicine.药物诱导和抑制心肌细胞和癌细胞中 GDF15 的分子基础及其在精准医疗中的应用。
Sci Rep. 2023 Jul 26;13(1):12061. doi: 10.1038/s41598-023-38450-w.
7
Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment.肿瘤来源的 GDF-15 阻断 LFA-1 依赖的 T 细胞募集并抑制抗 PD-1 治疗的反应。
Nat Commun. 2023 Jul 20;14(1):4253. doi: 10.1038/s41467-023-39817-3.
8
Neutralization of GDF15 Prevents Anorexia and Weight Loss in the Monocrotaline-Induced Cardiac Cachexia Rat Model.GDF15 中和可预防野百合碱诱导的心脏恶病质大鼠模型中的厌食和体重减轻。
Cells. 2022 Mar 23;11(7):1073. doi: 10.3390/cells11071073.
9
Development and progression of cancer cachexia: Perspectives from bench to bedside.癌症恶病质的发生与进展:从 bench 到 bedside 的视角
Sports Med Health Sci. 2020 Dec;2(4):177-185. doi: 10.1016/j.smhs.2020.10.003. Epub 2020 Dec 3.
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Proc Natl Acad Sci U S A. 2021 Feb 23;118(8). doi: 10.1073/pnas.2021357118.