Adami H O, Holmberg L, Malker B, Ries L
Br J Cancer. 1985 Jul;52(1):99-103. doi: 10.1038/bjc.1985.155.
Survival was analyzed during a follow-up period of up to 20 years in 406 (97%) of all 420 males in whom breast cancer was diagnosed in Sweden in 1960-1978. After correction for the expected mortality in the general population, cumulated survival rates (with 95% confidence limits) of 66 (58.7-72.5)% and 52 (42.0-62.1)% at 5 and 10 years respectively were found. These figures and the general pattern of relative survival rates were in close accordance with those noted in a concomitant series of female breast cancer. There was a trend toward slightly improved survival rates during the period of study and the median survival times were 3.9, 4.8 and 7.2 years for patients diagnosed in 1960-64, 1965-69 and 1970-74 respectively. Age at diagnosis was seemingly unrelated to the long-term relative survival. We conclude that, except for a slightly higher mean age at diagnosis in males, there is a striking similarity in the natural history of breast cancer between men and women after initial treatment, with an excess death rate which still persists at long-term observation.
对1960年至1978年期间在瑞典被诊断出患有乳腺癌的420名男性中的406名(97%)进行了长达20年的随访期生存分析。在校正了一般人群的预期死亡率后,发现5年和10年的累积生存率(95%置信区间)分别为66%(58.7 - 72.5%)和52%(42.0 - 62.1%)。这些数字以及相对生存率的总体模式与一系列同期的女性乳腺癌患者的数据非常一致。在研究期间,生存率有略微提高的趋势,1960 - 1964年、1965 - 1969年和1970 - 1974年诊断出的患者的中位生存时间分别为3.9年、4.8年和7.2年。诊断时的年龄似乎与长期相对生存率无关。我们得出结论,除了男性诊断时的平均年龄略高之外,男女乳腺癌在初始治疗后的自然病史有显著相似性,长期观察时仍存在较高的死亡率。