Lundegårdh G, Adami H O, Malker B
Ann Surg. 1986 Nov;204(5):546-51. doi: 10.1097/00000658-198611000-00007.
A total of 34,549 patients constituting 87.0% of all patients with gastric cancer diagnosed in Sweden in 1960-1978 and reported to the National Cancer Registry were included in a complete follow-up over a period of 1-20 years. The poor outcome in this disease was again established in this unselected material. Thus, the 5-year relative survival rate (with 95% confidence limits) was 12.7% (12.1-13.2%) among the men and 14.1% (13.4-14.9%) among the women, without any long-term difference between the sexes. The annual hazard rates in male and female patients were still 11.0% (8.3-13.7%) and 9.0% (7.1-10.9%), respectively, after 5 years and did not approach zero until 10 years after the diagnosis. Men older than 75 showed a slightly higher mortality during the first year, but there were seemingly no relationships of tumor-biological or clinical significance between age at diagnosis and long-term relative survival. The overall prognosis remained unchanged during the 19 years of the study, whereas the incidence was reduced by about 40% in the whole Swedish population.
共有34549名患者纳入了为期1至20年的完整随访，这些患者占1960 - 1978年在瑞典诊断出并报告给国家癌症登记处的所有胃癌患者的87.0%。在这个未经过筛选的样本中，再次证实了这种疾病的不良预后。因此，男性的5年相对生存率（95%置信区间）为12.7%（12.1 - 13.2%），女性为14.1%（13.4 - 14.9%），两性之间没有长期差异。5年后，男性和女性患者的年风险率分别仍为11.0%（8.3 - 13.7%）和9.0%（7.1 - 10.9%），直到诊断后10年才接近零。75岁以上的男性在第一年的死亡率略高，但诊断时的年龄与长期相对生存率之间似乎没有肿瘤生物学或临床意义上的关联。在这项研究的19年期间，总体预后保持不变，而瑞典全体人口的发病率下降了约40%。
