Lawrence C M, Shuster S
Br J Dermatol. 1985 Jul;113(1):117-22. doi: 10.1111/j.1365-2133.1985.tb02051.x.
The inflammatory dose-response to anthralin was measured in human skin 24 h after pretreatment with topical corticosteroids and anthralin, and 48 h after removal of the stratum corneum with adhesive tape. Anthralin inflammation was increased after 1% hydrocortisone application and decreased by 0.1% betamethasone valerate and 0.05% clobetasol propionate; although the difference between these effects was not significant, the difference between the effect of hydrocortisone and clobetasol propionate was. Anthralin inflammation was not significantly affected by pretreatment with anthralin and was reduced, although not significantly by removal of the stratum corneum. The finding that anthralin inflammation is not altered in skin in which aryl hydrocarbon hydroxylase (AHH) activity is increased and that anthralin inflammation may be altered in situations in which AHH activity is unchanged, excludes a direct relationship between anthralin inflammation and AHH activity.
在用外用皮质类固醇和蒽林预处理24小时后以及用胶带去除角质层48小时后，在人体皮肤中测量了对蒽林的炎症剂量反应。应用1%氢化可的松后蒽林炎症增加，而0.1%戊酸倍他米松和0.05%丙酸氯倍他索则使其降低；尽管这些效应之间的差异不显著，但氢化可的松和丙酸氯倍他索的效应之间存在差异。蒽林预处理对蒽林炎症没有显著影响，去除角质层虽未使其显著降低，但炎症有所减轻。蒽林炎症在芳烃羟化酶（AHH）活性增加的皮肤中未改变，而在AHH活性未改变的情况下蒽林炎症可能会改变，这一发现排除了蒽林炎症与AHH活性之间的直接关系。
