Nozaki Yumi, Yamamuro Minori, Tanaka Noriyoshi, Kamo Nobuyuki, Konishi Juichiro
Department of Medical Oncology, National Hospital Organization Saitama Hospital, Saitama, JPN.
Department of Breast Center, National Hospital Organization Saitama Hospital, Saitama, JPN.
Cureus. 2025 Feb 27;17(2):e79805. doi: 10.7759/cureus.79805. eCollection 2025 Feb.
Breast cancer brain metastases are among the most common distant metastases and have a poor prognosis. However, the effects of subtype-specific systemic therapy on breast cancer brain metastases are unknown. This report highlights the long-term control of breast cancer brain metastases using abemaciclib and letrozole combination therapy without severe side effects. We report a case of a middle-aged premenopausal female patient who experienced convulsions and was diagnosed with hormone receptor-positive breast cancer brain metastases. After standard-of-care whole-brain radiation therapy, systemic chemotherapy was administered, and the primary tumor and multiple brain metastases were sufficiently reduced. However, treatment was discontinued because peripheral neuropathy worsened. Abemaciclib, letrozole, and luteinizing hormone-releasing hormone agonists were administered as maintenance therapy. The treatment maintained a stable disease and no new lesions were observed. Cyclin-dependent kinase 4/6 inhibitors and endocrine maintenance therapy are effective treatments for breast cancer brain metastases.
乳腺癌脑转移是最常见的远处转移之一，预后较差。然而，亚型特异性全身治疗对乳腺癌脑转移的影响尚不清楚。本报告强调了使用阿贝西利和来曲唑联合治疗对乳腺癌脑转移的长期控制且无严重副作用。我们报告了一例中年绝经前女性患者，该患者出现惊厥，被诊断为激素受体阳性乳腺癌脑转移。在进行标准的全脑放射治疗后，给予全身化疗，原发肿瘤和多发脑转移灶充分缩小。然而，由于外周神经病变加重，治疗中断。给予阿贝西利、来曲唑和促性腺激素释放激素激动剂作为维持治疗。该治疗维持了疾病稳定，未观察到新的病灶。细胞周期蛋白依赖性激酶4/6抑制剂和内分泌维持治疗是乳腺癌脑转移的有效治疗方法。
