Deng Yu-Zhu, Song Bing
Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Department of Electrocardiogram, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230000, Anhui Province, China.
World J Cardiol. 2025 Mar 26;17(3):102999. doi: 10.4330/wjc.v17.i3.102999.
A significant proportion of cancer patients experience autonomic dysfunction, and cancer treatments such as chemotherapy and radiation therapy can exacerbate impairments in the cardiac autonomic nervous system. This study sought to investigate the characteristics of heart rate variability (HRV) in individuals with cancer.
To evaluate the relationship between HRV and cancer patients, providing insights and references for cancer treatment.
The study included 127 cancer patients with available 24-hour dynamic electrocardiogram data. HRV differences were analyzed using both time domain and frequency domain methods. These findings were then compared to HRV data from reference individuals, sourced from literature that utilized the same HRV computing algorithm.
Our findings revealed that cancer patients generally exhibited abnormal HRV compared to the reference group. HRV was found to be correlated with age and clinical type ( < 0.05), but no significant correlation was observed with tumor site or gender ( > 0.05).
This study indicates that cancer patients have significantly abnormal HRV compared to reference individuals, suggesting the presence of a certain level of cardiac autonomic dysfunction in this patient population.
相当一部分癌症患者存在自主神经功能障碍，化疗和放疗等癌症治疗方法会加重心脏自主神经系统的损害。本研究旨在调查癌症患者心率变异性（HRV）的特征。
评估HRV与癌症患者之间的关系，为癌症治疗提供见解和参考。
该研究纳入了127例有可用24小时动态心电图数据的癌症患者。使用时域和频域方法分析HRV差异。然后将这些结果与来自参考文献个体的HRV数据进行比较，这些参考文献使用相同的HRV计算算法。
我们的研究结果显示，与参考组相比，癌症患者的HRV普遍异常。发现HRV与年龄和临床类型相关（<0.05），但与肿瘤部位或性别无显著相关性（>0.05）。
本研究表明，与参考个体相比，癌症患者的HRV明显异常，提示该患者群体存在一定程度的心脏自主神经功能障碍。
