Moghaddam Mahdi, Dzemidzic Mario, Guerrero Daniel, Liu Mintao, Alessi Jonathan, Plawecki Martin H, Harezlak Jaroslaw, Kareken David A, Goñi Joaquín
Edwardson School of Industrial Engineering, Purdue University, West Lafayette, IN, USA.
Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA.
Netw Neurosci. 2025 Mar 3;9(1):38-60. doi: 10.1162/netn_a_00419. eCollection 2025.
Human brain function dynamically adjusts to ever-changing stimuli from the external environment. Studies characterizing brain functional reconfiguration are, nevertheless, scarce. Here, we present a principled mathematical framework to quantify brain functional reconfiguration when engaging and disengaging from a stop signal task (SST). We apply tangent space projection (a Riemannian geometry mapping technique) to transform the functional connectomes (FCs) of 54 participants and quantify functional reconfiguration using the correlation distance of the resulting tangent-FCs. Our goal was to compare functional reconfigurations in individuals at risk for alcohol use disorder (AUD). We hypothesized that functional reconfigurations when transitioning to/from a task would be influenced by family history of AUD (FHA) and other AUD risk factors. Multilinear regression models showed that engaging and disengaging functional reconfiguration were associated with FHA and recent drinking. When in the SST after a rest condition, functional reconfiguration was negatively associated with recent drinking, while functional reconfiguration when from the SST was negatively associated with FHA. In both models, several other factors contributed to the functional reconfiguration. This study demonstrates that tangent-FCs can characterize task-induced functional reconfiguration and that it is related to AUD risk.
人类大脑功能会动态调整以适应来自外部环境不断变化的刺激。然而，对大脑功能重新配置进行特征描述的研究却很稀少。在此，我们提出一个有原则的数学框架，用于量化在执行和脱离停止信号任务（SST）时大脑的功能重新配置。我们应用切空间投影（一种黎曼几何映射技术）来转换54名参与者的功能连接组（FCs），并使用所得切空间功能连接组的相关距离来量化功能重新配置。我们的目标是比较酒精使用障碍（AUD）风险个体的功能重新配置情况。我们假设在任务转换时的功能重新配置会受到AUD家族史（FHA）和其他AUD风险因素的影响。多线性回归模型表明，参与和脱离任务时的功能重新配置与FHA和近期饮酒有关。在休息状态后进入SST时，功能重新配置与近期饮酒呈负相关，而从SST脱离时的功能重新配置与FHA呈负相关。在这两个模型中，其他几个因素也对功能重新配置有影响。这项研究表明，切空间功能连接组可以表征任务诱导的功能重新配置，并且它与AUD风险相关。
