Didenko V V
Biull Eksp Biol Med. 1985 Jun;99(6):647-9.
The effect of myocardial infarction sustained by rats on the resistance of their isolated auricles to H2O2, an inductor of lipid peroxidation (LP), was studied. Atrial resistance to the LP inductor depends on the level of developed tension (DT) and the decrease of DT leads to augmentation of atrial resistance to the arrhythmogenic effect of LP. The experimental myocardial infarction causes appreciable disturbances in the function of automatism of the auricles, 60% of which lose their capability of spontaneous contractile activity. When compared with the control under equal DT, the auricles of the "infarction" series are less resistant to H2O2: the time of arrhythmias and arrests in them are 2.3 times as much as in the control. In infarction, the pretreatment with ionol reduces both the quantity of the auricles which stopped before H2O2 administration and the quantity of the auricles responding by arrhythmia to LP induction. The data point to the possibility of the use of antioxidants for preventing arrhythmias in experimental myocardial infarction.
研究了大鼠持续性心肌梗死对其离体心房抵抗脂质过氧化（LP）诱导剂H2O2能力的影响。心房对LP诱导剂的抵抗取决于所产生的张力（DT）水平，DT降低会导致心房对LP致心律失常作用的抵抗增强。实验性心肌梗死会引起心房自律功能的明显紊乱，其中60%的心房失去自发收缩活动的能力。在相同DT条件下与对照组相比，“梗死”组的心房对H2O2的抵抗力较弱：其中心律失常和停搏的时间是对照组的2.3倍。在梗死情况下，用生育酚预处理可减少在给予H2O2之前停止跳动的心房数量以及对LP诱导产生心律失常反应的心房数量。这些数据表明在实验性心肌梗死中使用抗氧化剂预防心律失常的可能性。
