Srinivasan Kishore, Hariharapura Raghu Chandrashekar, Mallikarjuna Subrahmanyam Volety
Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Environ Monit Assess. 2025 Mar 31;197(4):488. doi: 10.1007/s10661-025-13912-y.
Pharmaceuticals play a significant role in enhancing the quality of life. However, pharmaceutical products (PPs) manufacturing presents challenges, particularly in terms of waste generated, posing a risk to the ecosystem. Existing physical and chemical remediation methods are expensive and are not directly applicable for pharmaceutical remediation. Bioremediation using various microbial consortia has the potential to become a cost-effective solution when applied optimally. This review highlights the various pharmaceutical products, their occurrence in the environment, and their associated health risks. Further, various microorganisms employed in the bioremediation process and the techniques utilized to degrade diverse categories of pharmaceutical pollutants are discussed. Finally, the review highlights the limitations of using bioremediation for treating pharmaceutical waste and discusses alternative sustainable green pharmacy approaches to reduce the impact of pharmaceutical contaminants on the environment.
药物在提高生活质量方面发挥着重要作用。然而,药品(PPs)制造带来了挑战,尤其是在产生的废物方面,对生态系统构成风险。现有的物理和化学修复方法成本高昂,且不能直接应用于药品修复。当最佳应用时,使用各种微生物群落的生物修复有潜力成为一种具有成本效益的解决方案。本综述重点介绍了各种药品、它们在环境中的存在情况以及相关的健康风险。此外,还讨论了生物修复过程中使用的各种微生物以及用于降解不同类别的药物污染物的技术。最后,该综述强调了使用生物修复处理药物废物的局限性,并讨论了替代的可持续绿色制药方法,以减少药物污染物对环境的影响。