Sanmugam Anandhavelu, Vanitha C, Almansour Abdulrahman I, Karuppasamy K, Maiyalagan T, Kim Hyun-Seok, Vikraman Dhanasekaran, Alfantazi Akram
Department of Applied Chemistry, Sri Venkateswara College of Engineering, Sriperumbudur, 602117, India.
Department of Chemistry, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Avadi, Tamilnadu, India.
Sci Rep. 2025 Mar 31;15(1):10989. doi: 10.1038/s41598-024-82355-1.
This study presents the electrochemical sensing of dopamine (DA) using an electrode of polypyrrole/poly(3,4-ethylenedioxythiophene) (PEDOT-PPy) thin film. Electrochemical analyses of the PEDOT-PPy thin film for DA sensing were conducted through cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The CV analysis demonstrated that PEDOT-PPy exhibited superior electrochemical activity towards DA due to its enhanced conductivity as a high-conducting polymer composite. The DPV results indicated a linear concentration level of 5 nM to 200 µM with a minimal limit of sensing of 5 nM using the PEDOT-PPy electrode material. The fabricated sensor explored the sensitivity of 7.27 µA/µM cm at the 5 to 1000 nM DA concentration and the dopamine diffusion coefficient of 1.3 × 10 cm/s. Additionally, the PEDOT-PPy electrode material displayed excellent reproducibility, selectivity, and stability. Therefore, the PEDOT-PPy composite electrode material shows excellent potential for outperforming other electrode materials in detecting DA.
本研究展示了使用聚吡咯/聚（3,4-乙撑二氧噻吩）（PEDOT-PPy）薄膜电极对多巴胺（DA）进行电化学传感。通过循环伏安法（CV）和差分脉冲伏安法（DPV）对用于DA传感的PEDOT-PPy薄膜进行了电化学分析。CV分析表明，PEDOT-PPy作为一种高导电聚合物复合材料，由于其增强的导电性，对DA表现出优异的电化学活性。DPV结果表明，使用PEDOT-PPy电极材料时，线性浓度范围为5 nM至200 µM，最低检测限为5 nM。所制备的传感器在5至1000 nM的DA浓度下的灵敏度为7.27 µA/µM cm，多巴胺扩散系数为1.3×10 cm/s。此外，PEDOT-PPy电极材料表现出优异的重现性、选择性和稳定性。因此，PEDOT-PPy复合电极材料在检测DA方面显示出优于其他电极材料的巨大潜力。
