Ayati Ariyan, Khodabandelu Sajad, Khaleghi Sara, Nourmohammadi Anita, Jafari Farnaz, Ahmadianghalehsorkh Mina, Vatani Zahra, Bashiri Hanieh Sadat, Ahmadi Mahta, Jafari Mohammadsadegh, Soltaninejad Hossein, Rahmanian Mohammad
School of Medicine, Shahid Beheshti University of Medical Sciences, Postal code, Tehran, 19839-63113, Iran.
Department of Biostatistics and Epidemiology, Student Research Committee, School of Health, Mazandaran University of Medical Sciences, Postal code, Sari, 48175-866, Iran.
BMC Oral Health. 2025 Mar 31;25(1):463. doi: 10.1186/s12903-025-05830-9.
Several earlier studies have shown that IBD (including its two subtypes, ulcerative colitis (UC) and Crohn's disease (CD)) increases the risk of periodontal disease. This study aimed to evaluate the relevance among periodontitis and IBD subcategories.
This study was conducted based on PRISMA guidelines. The Web of Science, PubMed, Google Scholar, and Scopus databases were searched up to February 2024 using pertinent keywords. Case series, review articles, and animal studies were excluded. The risk of bias in this research was evaluated through the Joanna Briggs Institute (JBI) criteria. The meta-analysis was conducted using R statistical software.
A total of 9134 patients within 13 studies after the screening process were evaluated. Our study has shown that periodontitis is significantly more prevalent among IBD patients (UC and CD). According to prior meta-analyses, PD morbidity was found to be significantly high among CD patients (OR: 4.30; 95% CI: 3.72-4.98; I2 = 0%). Similarly, UC elevated PD risk (OR: 4.55; 95% CI: 3.76-5.50; I2 = 0%). The risk of periodontitis was not significantly different between CD and UC patients (OR: 0.96; 95% CI: 0.65-1.43; I2 = 34%).
UC and CD patients were more likely to develop periodontitis, with low heterogeneity between studies, while the prevalence of periodontitis among UC and CD patients was not meaningfully different.
The higher risk of periodontitis in patients with IBD indicates the necessity of screening for periodontitis. Considering the various oral manifestations and poor quality of life associated with IBD, it is important to be aware of the symptoms of periodontitis.
多项早期研究表明，炎症性肠病（包括其两种亚型，溃疡性结肠炎（UC）和克罗恩病（CD））会增加患牙周病的风险。本研究旨在评估牙周炎与炎症性肠病亚类之间的相关性。
本研究依据PRISMA指南进行。截至2024年2月，使用相关关键词在科学网、PubMed、谷歌学术和Scopus数据库中进行检索。排除病例系列、综述文章和动物研究。通过乔安娜·布里格斯研究所（JBI）标准评估本研究中的偏倚风险。使用R统计软件进行荟萃分析。
筛选过程后，共评估了13项研究中的9134名患者。我们的研究表明，牙周炎在炎症性肠病患者（UC和CD）中显著更为普遍。根据先前的荟萃分析，发现CD患者中牙周病发病率显著较高（比值比：4.30；95%置信区间：3.72 - 4.98；I² = 0%）。同样，UC增加了患牙周病的风险（比值比：4.55；95%置信区间：3.76 - 5.50；I² = 0%）。CD和UC患者之间牙周炎的风险没有显著差异（比值比：0.96；95%置信区间：0.65 - 1.43；I² = 34%）。
UC和CD患者更易患牙周炎，研究间异质性较低，而UC和CD患者中牙周炎的患病率没有显著差异。
炎症性肠病患者患牙周炎的风险较高，这表明有必要对牙周炎进行筛查。考虑到与炎症性肠病相关的各种口腔表现和较差的生活质量，了解牙周炎的症状很重要。
