Isler Madeleine F, Coates Sarah J, Boos Markus D
WWAMI Medical Education, University of Wyoming, Laramie, WY, USA.
School of Medicine, WWAMI Medical Education, University of Washington, Seattle, WA, USA.
Int J Dermatol. 2023 Mar;62(3):337-345. doi: 10.1111/ijd.16297. Epub 2022 May 22.
The skin plays an important role in human health by providing barrier protection against environmental stressors. In addition to human skin cells, the cutaneous barrier is also home to a network of organisms that have co-evolved with humans, referred to as the cutaneous microbiome. This network has been demonstrated to play an active role in skin health and the manifestation of cutaneous disease. Here, we review how a warming world and its attendant changes in climatic variables, including temperature, humidity, ultraviolet radiation, and air pollution, influence the cutaneous microbiome and, in turn, skin health. Studies indicate that the cutaneous microbiome is affected by these factors, and these changes may influence the epidemiology and severity of cutaneous disorders including atopic dermatitis, acne vulgaris, psoriasis, and skin cancer. Further investigation into how the cutaneous microbiome changes in response to climate change and subsequently influences skin disease is needed to better anticipate future dermatologic needs and potentially generate novel therapeutic solutions in response.
皮肤通过提供针对环境应激源的屏障保护，在人类健康中发挥着重要作用。除了人类皮肤细胞外，皮肤屏障也是一个与人类共同进化的生物网络的家园，这个网络被称为皮肤微生物群。已经证明这个网络在皮肤健康和皮肤疾病的表现中发挥着积极作用。在这里，我们综述了气候变暖及其伴随的气候变量变化，包括温度、湿度、紫外线辐射和空气污染，如何影响皮肤微生物群，进而影响皮肤健康。研究表明，皮肤微生物群会受到这些因素的影响，而这些变化可能会影响包括特应性皮炎、寻常痤疮、银屑病和皮肤癌在内的皮肤疾病的流行病学和严重程度。需要进一步研究皮肤微生物群如何响应气候变化而发生变化，以及随后如何影响皮肤疾病，以便更好地预测未来的皮肤病学需求，并有可能产生新的治疗方案。
