Smith Patrick J, Drescher Christopher F, Bruschwein Heather, Ingle Krista, Nurse Chelsi, O'Hayer Catherine Virginia
Biopsychosoc Sci Med. 2025 May 1;87(4):271-279. doi: 10.1097/PSY.0000000000001387. Epub 2025 Mar 24.
An emerging body of evidence suggests that psychological flexibility may be an important and underexamined determinant of overall psychological functioning. The chronic nature of cystic fibrosis (CF) may require a greater level of flexibility to navigate complex and dynamic health concerns in an increasingly aging population.
We examined associations between psychological flexibility, coping styles, psychological grit, and negative affectivity (anxiety and depressive symptoms) from baseline assessments of randomized trials among adults with CF. Regression models controlling for age, sex, income, psychotropic medication use, and pulmonary function were used to characterize associations between psychological flexibility, coping styles, and negative affect.
A total of 124 individuals were included in analyses, 74 (60%) of whom were taking psychotropic medication. Depressive [Beck Depression Inventory-II = 18.6 (SD = 9.9)] and anxious [Beck Anxiety Inventory = 13.8 (SD = 9.3)] symptoms were both elevated. Greater levels of psychological flexibility were associated with lower negative affect, such that individuals reporting less cognitive fusion (B = -0.59, p < .001) and greater psychological acceptance (B = -0.51. p < .001) exhibited lesser levels of anxiety and depressive symptoms. Psychological flexibility was the most robust correlate of negative affect after accounting for other coping variables (B = -0.50, p < .001), and this association was not moderated by forced expiratory volume in 1 second/forced vital capacity levels.
Psychological flexibility is robustly associated with decreased negative affect among individuals with CF, independent of background and clinical characteristics.
越来越多的证据表明，心理灵活性可能是整体心理功能的一个重要但未得到充分研究的决定因素。囊性纤维化（CF）的慢性性质可能需要更高水平的灵活性，以便在日益老龄化的人群中应对复杂多变的健康问题。
我们在成年CF患者随机试验的基线评估中，研究了心理灵活性、应对方式、心理韧性和消极情感（焦虑和抑郁症状）之间的关联。使用控制年龄、性别、收入、精神药物使用和肺功能的回归模型来描述心理灵活性、应对方式和消极情感之间的关联。
共有124人纳入分析，其中74人（60%）正在服用精神药物。抑郁症状[贝克抑郁量表-II = 18.6（标准差 = 9.9）]和焦虑症状[贝克焦虑量表 = 13.8（标准差 = 9.3）]均有所升高。更高水平的心理灵活性与更低的消极情感相关，即报告认知融合程度较低（B = -0.59，p <.001）和心理接纳程度较高（B = -0.51，p <.001）的个体焦虑和抑郁症状水平较低。在考虑其他应对变量后，心理灵活性是消极情感最有力的相关因素（B = -0.50，p <.001），且这种关联不受一秒用力呼气量/用力肺活量水平的调节。
心理灵活性与CF患者消极情感的降低密切相关，独立于背景和临床特征。
