Kalule John Bosco, Nakintu Zalwango Valeria, Kyazike Pauline, Majalija Samuel
Department of Biotechnical and Diagnostic Sciences (BDS), College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala, Uganda.
National Livestock Resources Research Institute (NALIRRI), National Agricultural Research Organization (NARO), Namulonge, Uganda.
Am J Trop Med Hyg. 2025 Apr 1;112(6):1256-1259. doi: 10.4269/ajtmh.24-0772. Print 2025 Jun 4.
Drug-resistant invasive non-typhoidal Salmonella poses a significant challenge to the management of acute febrile illnesses in Uganda. However, the characteristics of invasive non-typhoidal Salmonella strains are not yet well understood. This study aimed to determine the serotypes and antimicrobial resistance patterns of invasive non-typhoidal Salmonella isolates from a local health center in Uganda. Invasive non-typhoidal Salmonella isolates archived over 5 years from febrile patients at a local health center were characterized for serotypes and antimicrobial susceptibility patterns using conventional methods. Among the 80 archived isolates, 18 serotypes of invasive non-typhoidal Salmonella were identified, with Salmonella Typhimurium (42.5%), Salmonella Enteritidis (20%), and Salmonella Haifa (8.8%) being the most prevalent. A total of 81.3% (65/80) of the isolates exhibited resistance to at least one antibiotic, with the highest resistance rates observed for streptomycin (72.5%), trimethoprim-sulfamethoxazole (66.2%), and ampicillin (56.2%). The most common antimicrobial resistance profile, found in 23.1% (15/65) of resistant isolates, was Amp-C-S10-S300-SXT. Notably, 81.5% of the drug-resistant isolates were multi-drug resistant. Invasive non-typhoidal Salmonella in this setting have a high rate of antimicrobial resistance to commonly used antibiotics. Improved treatment guidelines could be adapted for better clinical outcomes.
耐药物侵袭性非伤寒沙门氏菌对乌干达急性发热性疾病的治疗构成了重大挑战。然而，侵袭性非伤寒沙门氏菌菌株的特征尚未得到充分了解。本研究旨在确定乌干达当地一家卫生中心侵袭性非伤寒沙门氏菌分离株的血清型和抗菌药物耐药模式。使用传统方法对当地一家卫生中心5年来存档的发热患者的侵袭性非伤寒沙门氏菌分离株进行血清型和抗菌药物敏感性模式鉴定。在80株存档分离株中，鉴定出18种侵袭性非伤寒沙门氏菌血清型，其中鼠伤寒沙门氏菌（42.5%）、肠炎沙门氏菌（20%）和海法沙门氏菌（8.8%）最为常见。共有81.3%（65/80）的分离株对至少一种抗生素耐药，对链霉素（72.5%）、甲氧苄啶-磺胺甲恶唑（66.2%）和氨苄西林（56.2%）的耐药率最高。在23.1%（15/65）的耐药分离株中发现的最常见抗菌药物耐药谱为Amp-C-S10-S300-SXT。值得注意的是，81.5%的耐药分离株为多重耐药。在这种情况下，侵袭性非伤寒沙门氏菌对常用抗生素的耐药率很高。可以调整改进治疗指南以获得更好的临床结果。
