Tian Shuang, Xu Pengliang
Department of Health and Geriatric, Dongying People'S Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying, 257091, Shandong Province, China.
Department of Pharmacy, Dongying People'S Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying, 257091, Shandong Province, China.
Mol Biotechnol. 2025 Apr 1. doi: 10.1007/s12033-025-01427-3.
To evaluate the perioperative outcomes of a novel anatomical nano-cage in elderly patients undergoing anterior discectomy and interbody fusion, with special attention to its outcomes on clinical symptoms, interbody fusion stability, and surgery-related complications.
twenty-four cases of elderly surgical patients were divided into control group 1 (Cntrl 1), control group 2 (Cntrl 2), control group 3 (Cntrl 3), and the Experimental group (Exptl), 6 cases in each group. The polyetheretherketone interbody fusion cage was used in Cntrl 1 group, the titanium alloy interbody fusion cage was used in Cntrl 2 group, the spine minimally invasive interbody fusion cage was used in Cntrl 3 group, and the nano-hydroxyapatite/polyamide 66 (nHA/PA66) interbody fusion cage was used in Exptl group. All patients received anterior discectomy and interbody fusion, and received perioperative nursing intervention. The management of postoperative complications and patient observation indexes were recorded in detail.
The fusion of the fusion cage was better in the Exptl group than in the Cntrl group after surgery. At 2 weeks, 3 months, and 6 months after operation, the intervertebral space height of Exptl group was higher than that of Cntrl group (P < 0.05). Visual analogue scale (VAS) was lower in Exptl group than in Cntrl group (P < 0.05). At 2 weeks and 3 months after surgery, Japanese Orthopaedic Association (JOA) scores were higher in Exptl group than in Cntrl group (P < 0.05). Complications occurred more frequently in the Exptl group than in the Cntrl group.
the novel anatomical nano-interbody fusion markedly improved the stability, the effective implementation of perioperative care reduced the incidence of complications, and the postoperative follow-up suggested that the successful application of interbody fusion cage had a positive impact on the overall rehabilitation of patients.
为评估新型解剖学纳米椎间融合器在接受前路椎间盘切除及椎间融合术的老年患者中的围手术期结果,特别关注其对临床症状、椎间融合稳定性及手术相关并发症的影响。
24例老年手术患者分为对照组1(Cntrl 1)、对照组2(Cntrl 2)、对照组3(Cntrl 3)和实验组(Exptl),每组6例。Cntrl 1组使用聚醚醚酮椎间融合器,Cntrl 2组使用钛合金椎间融合器,Cntrl 3组使用脊柱微创椎间融合器,Exptl组使用纳米羟基磷灰石/聚酰胺66(nHA/PA66)椎间融合器。所有患者均接受前路椎间盘切除及椎间融合术,并接受围手术期护理干预。详细记录术后并发症的处理情况及患者观察指标。
术后实验组融合器的融合情况优于对照组。术后2周、3个月和6个月,实验组的椎间隙高度高于对照组(P<0.05)。实验组的视觉模拟评分(VAS)低于对照组(P<0.05)。术后2周和3个月,实验组的日本骨科协会(JOA)评分高于对照组(P<0.05)。实验组并发症的发生率高于对照组。
新型解剖学纳米椎间融合显著提高了稳定性,围手术期护理的有效实施降低了并发症的发生率,术后随访表明椎间融合器的成功应用对患者的整体康复有积极影响。