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易感BALB/c小鼠针对巴西利什曼原虫的免疫接种。II. 利用寄生虫的温度敏感无毒克隆进行疫苗接种

Immunization of susceptible BALB/c mice against Leishmania braziliensis. II. Use of temperature-sensitive avirulent clones of parasite for vaccination purposes.

作者信息

Gorczynski R M

出版信息

Cell Immunol. 1985 Aug;94(1):11-20. doi: 10.1016/0008-8749(85)90081-4.

DOI:10.1016/0008-8749(85)90081-4
PMID:4016960
Abstract

Avirulent clones of Leishmania braziliensis were produced by treatment of parental parasite stock with the mutagen N-methyl-N'-methyl-N'-nitro-N-nitrosoguanidine and selection for growth at 19 degrees C. These clones have a clear preference for infection and growth in vitro at 19 degrees C rather than the normal 28 degrees C. In addition, they can be used to vaccinate naive mice successfully against growth of the parental parasite clones. Immunity can be adoptively transferred from vaccinated mice by Lyt-1+ cells from immunized animals.

摘要

通过用诱变剂N-甲基-N'-甲基-N'-硝基-N-亚硝基胍处理亲本寄生虫原种，并选择在19℃下生长，获得了巴西利什曼原虫的无毒克隆。这些克隆明显更倾向于在19℃而非正常的28℃下进行体外感染和生长。此外，它们可用于成功地给未感染的小鼠接种疫苗，以抵抗亲本寄生虫克隆的生长。免疫可通过来自免疫动物的Lyt-1+细胞从接种疫苗的小鼠进行过继转移。

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