Preliminary findings from a retrospective comparative study on a novel hydrophobic C-loop monofocal intraocular lens.

To investigate visual outcomes and optical performance of a new non-constant aberration aspheric monofocal intraocular lens (IOL). This study included consecutive patients who underwent phacoemulsification with implantation of either the CT LUCIA 621P intraocular lens (Carl Zeiss Meditec AG, Jena, Germany; 32 eyes, 25 patients) or the Tecnis ZCB00 intraocular lens (Johnson & Johnson Vision, Santa Ana, CA, USA; 38 eyes, 27 patients). Monocular uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), uncorrected intermediate visual acuity (UIVA), and objective optical quality were measured 3 months after surgery. The optical bench test measured the root mean square of the modulation transfer function (MTT) of each IOL at defocus levels between +1.00 D and -2.50 D at intervals of 0.25 D at varying pupil sizes (2.0-5.0 mm) in 1.0 mm steps. There was no difference in UDVA, UNVA, and objective optical quality between CT LUCIA and ZCB00 groups. On the other hand, UIVA was higher in the CT LUCIA group (0.19 ± 0.12 logMAR) compared to the ZCB00 group (0.32 ± 0.05 logMAR; p < 0.001). For all tested pupil sizes, the MTF values for both CT LUCIA and ZCB00 IOLs were similar across defocus ranges from +1.00 to -0.75 D. However, the CT LUCIA IOL consistently exhibited higher MTF values than the ZCB00 IOL at defocus levels from -1.25 to - 2.50 D. The CT LUCIA IOL provides comparable distance visual acuity and optical quality to ZCB00 IOL, with superior performance at intermediate distances.