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人工智能在癌症治疗的基因组医学中的应用日益增加——前景与潜在风险。

Increasing use of artificial intelligence in genomic medicine for cancer care- the promise and potential pitfalls.

作者信息

O'Connor Olivia, McVeigh Terri P

机构信息

Frimley Health NHS Foundation Trust, England, UK.

Cancer Genetics Unit, The Royal Marsden NHS Foundation Trust, England, UK.

出版信息

BJC Rep. 2025 Apr 1;3(1):20. doi: 10.1038/s44276-025-00135-4.

Abstract

The field of genomic medicine produces large datasets, which need to be rapidly analysed to produce clinically actionable insights in cancer care. Artificial intelligence thrives on data, processing and learning from datasets with a degree of accuracy and efficiency that traditional computing algorithms can not achieve. Based on a patient's genome sequence, AI could allow earlier detection of cancer, inform personalised treatment plans and provide insights into prognostication. However, this valuable tool is met with skepticism, with stakeholders concerned over data security, liability for AI's mistakes due to hallucination and the threat to clinical jobs. This review highlights both the benefits and potential problems of using AI in genomic medicine for cancer care, with the aim to lessen the knowledge gap between clinicians and data scientists and facilitate the future deployment of AI in cancer care.

摘要

基因组医学领域产生了大量数据集,需要对其进行快速分析,以便在癌症治疗中得出具有临床可操作性的见解。人工智能借助数据蓬勃发展,能够以传统计算算法无法企及的准确度和效率对数据集进行处理和学习。基于患者的基因组序列,人工智能可以实现癌症的早期检测,为个性化治疗方案提供依据,并对预后情况提供见解。然而,这一宝贵工具却遭到了质疑,利益相关者担心数据安全、人工智能因幻觉产生错误的责任问题以及对临床工作的威胁。本综述着重介绍了在癌症治疗的基因组医学中使用人工智能的益处和潜在问题,旨在缩小临床医生和数据科学家之间的知识差距,并促进人工智能在癌症治疗中的未来应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d66/11962076/73c640554a02/44276_2025_135_Fig1_HTML.jpg

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