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The emerging landscape of engineered bacteria cancer therapies.

作者信息

Ballister Edward R, Michels Alexander, Vincent Rosa L, Kreindler Lior, Chowdhury Sreyan, Upadhaya Samik, Saez-Ibañez Ana Rosa, Tu Tao, Gottweis Juraj, Danino Tal

机构信息

Department of Biomedical Engineering, Columbia University, New York, NY, USA.

Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons of Columbia University, New York, NY, USA.

出版信息

Nat Biotechnol. 2025 May;43(5):672-676. doi: 10.1038/s41587-025-02623-x.

DOI:10.1038/s41587-025-02623-x
PMID:40169920
Abstract
摘要

相似文献

1
The emerging landscape of engineered bacteria cancer therapies.工程菌癌症治疗的新前景。
Nat Biotechnol. 2025 May;43(5):672-676. doi: 10.1038/s41587-025-02623-x.
2
Engineered bacteria in tumor immunotherapy.肿瘤免疫治疗中的工程菌。
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4
Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy.协同生辉:工程菌与纳米医学在癌症治疗中联合。
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Natural killer cells in clinical development as non-engineered, engineered, and combination therapies.临床开发中的自然杀伤细胞作为非工程化、工程化和联合疗法。
J Hematol Oncol. 2022 Nov 8;15(1):164. doi: 10.1186/s13045-022-01382-5.
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Tweak to Treat: Reprograming Bacteria for Cancer Treatment.微调以治疗:为癌症治疗重新编程细菌。
Trends Cancer. 2021 May;7(5):447-464. doi: 10.1016/j.trecan.2020.11.004. Epub 2020 Dec 8.
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Potential applications of engineered bacteria in disease diagnosis and treatment.工程菌在疾病诊断与治疗中的潜在应用。
Microbiome Res Rep. 2024 Dec 17;4(1):10. doi: 10.20517/mrr.2024.57. eCollection 2025.
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Physiochemically and Genetically Engineered Bacteria: Instructive Design Principles and Diverse Applications.理化遗传修饰细菌:设计原理与多样应用
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Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology.利用合成生物学构建用于疾病诊断与治疗的工程菌
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Hypoxia-targeted and spatial-selective tumor suppression by near infrared nanoantenna sensitized engineered bacteria.近红外纳米天线敏化工程菌实现缺氧靶向和空间选择性肿瘤抑制
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本文引用的文献

1
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models.CRISPR-StAR技术可在复杂的体内模型中实现高分辨率基因筛选。
Nat Biotechnol. 2024 Dec 16. doi: 10.1038/s41587-024-02512-9.
2
Exploiting bacteria for cancer immunotherapy.利用细菌进行癌症免疫疗法。
Nat Rev Clin Oncol. 2024 Aug;21(8):569-589. doi: 10.1038/s41571-024-00908-9. Epub 2024 Jun 5.
3
Intracellular delivery of oncolytic viruses with engineered Salmonella causes viral replication and cell death.经工程改造的沙门氏菌实现溶瘤病毒的细胞内递送可引发病毒复制和细胞死亡。
iScience. 2024 Apr 25;27(6):109813. doi: 10.1016/j.isci.2024.109813. eCollection 2024 Jun 21.
4
Probiotic-guided CAR-T cells for solid tumor targeting.益生菌引导的 CAR-T 细胞用于实体瘤靶向治疗。
Science. 2023 Oct 13;382(6667):211-218. doi: 10.1126/science.add7034. Epub 2023 Oct 12.
5
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics.基于大肠杆菌 Nissle 1917 的治疗方法的新兴工程策略。
Trends Pharmacol Sci. 2022 Sep;43(9):772-786. doi: 10.1016/j.tips.2022.02.002. Epub 2022 Feb 26.
6
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria.经鞭毛细菌注射将抗原转运至肿瘤周边,引发肿瘤的全身免疫反应。
Nat Biomed Eng. 2022 Jan;6(1):44-53. doi: 10.1038/s41551-021-00834-6. Epub 2022 Jan 20.
7
Tweak to Treat: Reprograming Bacteria for Cancer Treatment.微调以治疗:为癌症治疗重新编程细菌。
Trends Cancer. 2021 May;7(5):447-464. doi: 10.1016/j.trecan.2020.11.004. Epub 2020 Dec 8.
8
The human tumor microbiome is composed of tumor type-specific intracellular bacteria.人类肿瘤微生物组由肿瘤类型特异性的内共生细菌组成。
Science. 2020 May 29;368(6494):973-980. doi: 10.1126/science.aay9189.
9
A guide to cancer immunotherapy: from T cell basic science to clinical practice.癌症免疫疗法指南:从 T 细胞基础科学到临床实践。
Nat Rev Immunol. 2020 Nov;20(11):651-668. doi: 10.1038/s41577-020-0306-5. Epub 2020 May 20.
10
Bacteria-cancer interactions: bacteria-based cancer therapy.细菌-癌症相互作用:基于细菌的癌症疗法。
Exp Mol Med. 2019 Dec 11;51(12):1-15. doi: 10.1038/s12276-019-0297-0.