Briese Thorben, Peez Christian, Albert Alina, Große-Allermann Arian, Herbst Elmar, Deichsel Adrian, Raschke Michael J, Kittl Christoph
Department of Trauma, Hand and Reconstructive Surgery University Hospital Muenster Muenster Germany.
J Exp Orthop. 2025 Mar 31;12(2):e70225. doi: 10.1002/jeo2.70225. eCollection 2025 Apr.
Avulsion fractures of the posterior cruciate ligament (PCL) are commonly treated with refixation. Headless compression screws (HCS) offer benefits, compared to conventional techniques, such as reduced material irritation and option of bioabsorbable materials, possibly avoiding implant removal. Proofing its clinical applicability, the authors hypothesized that (1) biomechanical properties of HCS would be comparable to conventional techniques and (2) magnesium-based HCS would provide comparable properties to titanium HCS.
Controlled laboratory study.
Forty fresh frozen porcine knees were dissected keeping the menisci and ligaments intact. A solid avulsion fracture of the tibial PCL (20 mm [length] × 20 mm [width] × 10 mm [depth]) was created with a chisel. Specimens were randomized into four groups: (1) the native PCL, the tibial PCL avulsion refixed with parallel arranged, (2) two 3.5 mm cortical screws with washer (Ti-CS), (3) two titanium headless compression screws (Ti-HCS) or (4) two magnesium based headless compression screws (Mg-HCS). Femur and tibia were mounted in a universal uniaxial testing machine (Zwick) simulating a posterior drawer testing, by performing axial load on the femur while the tibia was fixed in 90° flexion. After preconditioning, 500 cycles (200 mm/min) were performed with 10-100 N, followed by load-to-failure (LTF). Key parameters measured included stiffness, yield load, LTF and cyclic displacement. Differences were analyzed using an analysis of variance with a significance level of < 0.05. The macroscopic failure mode was documented.
LTF of the intact PCL (1982.0 ± 285.4 N; ≤ 0.001) significantly exceeded that of all refixations. Whereas LTF of Ti-CS (1034.8 ± 236.1 N) significantly ( ≤ 0.01) exceeded those of HCS, no significance was seen between titanium (Ti-HCS: 693.9 ± 220.5 N) or magnesium (Mg-HCS: 686.7 ± 174.6 N) based HCS. No significant differences were found among the refixation methods regarding cyclic displacement or yield load. Stiffness for the Ti-CS (144.0 ± 15.4 N/mm), Ti-HCS (150.0 ± 22.9 N/mm) and Mg-HCS (170.0 ± 20.9 N/mm) was lower than that of the intact PCL (190.9 ± 8.6 N/mm). Failure modes varied, with the Ti-CS group showing PCL tears and the HCS groups always experiencing fragment luxation.
In our biomechanical model, all fixation techniques demonstrated inferior biomechanical properties compared to the native PCL. Both HCS exhibited similar displacement, stiffness, and yield load values but showed a significantly lower LTF with fragment dislocation compared to conventional screws. Whether this difference is clinically relevant cannot be determined with this model as the porcine model only allows limited transfer into the clinical setting but might limit rehabilitation in the application of HCS in cases of solid avulsion fractures. Further clinical and in vivo studies should be followed to further differentiate the optimized fragment refixation technique.
There is no level of evidence as this study was an experimental laboratory study.
后交叉韧带(PCL)撕脱骨折通常采用重新固定治疗。与传统技术相比,无头加压螺钉(HCS)具有诸多优势,如减少材料刺激以及可选用生物可吸收材料,可能避免植入物取出。为证明其临床适用性,作者假设:(1)HCS的生物力学性能与传统技术相当;(2)镁基HCS与钛制HCS具有相当的性能。
对照实验室研究。
解剖40个新鲜冷冻猪膝关节,保持半月板和韧带完整。用凿子制造胫骨PCL的坚实撕脱骨折(长20mm×宽20mm×深10mm)。标本随机分为四组:(1)完整PCL组;(2)用两枚平行排列的3.5mm皮质骨螺钉加垫圈固定的胫骨PCL撕脱骨折组(Ti-CS);(3)两枚钛制无头加压螺钉固定组(Ti-HCS);(4)两枚镁基无头加压螺钉固定组(Mg-HCS)。将股骨和胫骨安装在万能单轴试验机(Zwick)上模拟后抽屉试验,在固定胫骨于90°屈曲位时对股骨施加轴向负荷。预处理后,以10 - 100N进行500次循环(200mm/min),随后进行破坏载荷试验(LTF)。测量的关键参数包括刚度、屈服载荷、破坏载荷和循环位移。采用方差分析进行差异分析,显著性水平为<0.05。记录宏观破坏模式。
完整PCL的破坏载荷(1982.0±285.4N;≤0.001)显著超过所有重新固定组。Ti-CS组的破坏载荷(1034.8±236.1N)显著(≤0.01)超过HCS组,而钛制(Ti-HCS:693.9±220.5N)和镁基(Mg-HCS:686.7±174.6N)HCS组之间无显著差异。在循环位移或屈服载荷方面,重新固定方法之间未发现显著差异。Ti-CS组(144.0±15.4N/mm)、Ti-HCS组(150.0±22.9N/mm)和Mg-HCS组(170.0±20.9N/mm)的刚度低于完整PCL组(190.9±8.6N/mm)。破坏模式各不相同,Ti-CS组表现为PCL撕裂,而HCS组总是出现骨折块移位。
在我们的生物力学模型中,与完整PCL相比,所有固定技术的生物力学性能均较差。两种HCS在位移、刚度和屈服载荷值方面相似,但与传统螺钉相比,其破坏载荷显著较低,且伴有骨折块脱位。由于猪模型仅允许有限地转化到临床情况,该模型无法确定这种差异是否具有临床相关性,但可能会限制HCS在坚实撕脱骨折病例中的应用及康复。应开展进一步的临床和体内研究,以进一步区分优化的骨折块重新固定技术。
由于本研究是一项实验性实验室研究,故无证据水平。