Peng Hui, Wang Bin, Yang Wei, Jia Rui, Luo Youlian, Chen Weifeng
Department of General Practice, Shenzhen second People's Hospital (The First Affiliated of Shenzhen University), Shenzhen, Guangdong, 518000, People's Republic of China.
J Multidiscip Healthc. 2025 Mar 28;18:1779-1790. doi: 10.2147/JMDH.S510549. eCollection 2025.
The association between triglyceride(TG) levels and the risk of diabetes mellitus (DM) continues to be a subject of considerable interest and debate within the scientific community. To date, there has been a lack of studies specifically examining this relationship within the Chinese population. This study seeks to elucidate the correlation between TG levels and the incidence of DM among the Chinese demographic.
This study constitutes a secondary analysis of a retrospective cohort investigation comprising 202,888 Chinese participants who were free of DM at baseline and were subsequently followed from 2010 to 2016. Cox regression method and sensitivity analyses were used to examine the relationship between TG levels and DM. To examine the potential non-linear relationship between TG levels and the incidence of DM, Cox proportional hazards regression incorporating cubic spline functions and smooth curve fitting was employed. Additionally, a two-piece Cox proportional hazards regression model was utilized to identify the inflection point at which TG levels influence the risk of developing DM.
In participants with DM, baseline TG levels were elevated. After adjusting for confounding variables, baseline TG levels were positively associated with incident DM. (HR:1.25,95% CI:1.21-1.30,P<0.001). In addition, we conducted sensitivity analyses to ensure the results were robust. There was a 88% increase in DM risk from the top TG tertile to the bottom TG tertile.Our research discovered a significant link between TG and DM when TG levels were below 1.27 mmol/L (HR:2.35, 95% CI: 1.95-2.83,P < 0.001).
This study shows that TG was positively and non-linearly associated with the risk of DM after adjusting for other confounding factors.Below 1.27 mmol/L, increasing TG levels greatly heighten the risk of DM, whereas above this level, the risk is lower.
甘油三酯（TG）水平与糖尿病（DM）风险之间的关联一直是科学界相当感兴趣且存在争议的话题。迄今为止，缺乏专门针对中国人群研究这种关系的研究。本研究旨在阐明中国人群中TG水平与DM发病率之间的相关性。
本研究是对一项回顾性队列研究的二次分析，该队列研究包括202,888名基线时无DM的中国参与者，他们在2010年至2016年期间接受随访。采用Cox回归方法和敏感性分析来检验TG水平与DM之间的关系。为了检验TG水平与DM发病率之间潜在的非线性关系，采用了纳入三次样条函数和光滑曲线拟合的Cox比例风险回归。此外，使用两段式Cox比例风险回归模型来确定TG水平影响患DM风险的拐点。
在患有DM的参与者中，基线TG水平升高。在调整混杂变量后，基线TG水平与新发DM呈正相关（HR：1.25，95%CI：1.21 - 1.30，P<0.001）。此外，我们进行了敏感性分析以确保结果的稳健性。从TG最高三分位数到最低三分位数，DM风险增加了88%。我们的研究发现，当TG水平低于1.27 mmol/L时，TG与DM之间存在显著关联（HR：2.35，95%CI：1.95 - 2.83，P<0.001）。
本研究表明，在调整其他混杂因素后，TG与DM风险呈正相关且是非线性的。低于1.27 mmol/L时，TG水平升高会大大增加DM风险，而高于此水平，风险则较低。
